2. Gene
  3. SUPT3H - SPT3 homolog, SAGA and STAGA complex component Gene

SUPT3H - SPT3 homolog, SAGA and STAGA complex component Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：SPT3 同系物、SAGA 和 STAGA 复杂成分

种属: Homo sapiens

同用名: SPT3; SPT3L

基因 ID: 8464 | 基因类型: protein coding

关于 SUPT3H

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,809,057-45,377,934 (from NCBI)

This gene has 7 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 1.4), ovary (RPKM 1.0) and 24 other tissues.

功能概要

启用转录共激活因子活性。参与组蛋白 H3 乙酰化和组蛋白去泛素化。位于核质中。 SAGA 复合体和转录因子 TFTC 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables transcription coactivator activity. Involved in histone H3 acetylation and histone deubiquitination. Located in nucleoplasm. Part of SAGA complex and transcription factor TFTC complex. [provided by Alliance of Genome Resources, Apr 2022]

SUPT3H 基因产物(8)

mRNA Protein Name
NM_001261823.2 NP_001248752.1 transcription initiation protein SPT3 homolog isoform 3
NM_001350324.2 NP_001337253.1 transcription initiation protein SPT3 homolog isoform 4
NM_001350325.2 NP_001337254.1 transcription initiation protein SPT3 homolog isoform 5
NM_001350326.2 NP_001337255.1 transcription initiation protein SPT3 homolog isoform 6
NM_001350327.2 NP_001337256.1 transcription initiation protein SPT3 homolog isoform 7
NM_001350329.2 NP_001337258.1 transcription initiation protein SPT3 homolog isoform 1
NM_003599.4 NP_003590.1 transcription initiation protein SPT3 homolog isoform 1
NM_181356.3 NP_852001.1 transcription initiation protein SPT3 homolog isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
11564863 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9603525 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SAGA complex IDA
IDA: 通过直接分析推断
11564863 GOA
located in nucleus IDA
IDA: 通过直接分析推断
9726987 GOA
part of transcription factor TFTC complex IDA
IDA: 通过直接分析推断
10373431 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SUPT3H 蛋白结构

TFIID-18kDa

TFIID-18kDa: Transcription initiation factor IID, 18kD subunit (46 - 127)

  • 0
  • 100
  • 200
  • 300
  • 328 a.a.
蛋白主名 其他名称

transcription initiation protein SPT3 homolog

SPT3-like protein

关联疾病

疾病名称 别名
Cleidocranial Dysplasia

Cleidocranial Dysostosis

CLCD

Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies Only

Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly

CCD

Marie-Sainton Disease

Dysplasia Cleidocranial

Dento-Osseous Dysplasia

Marie-Sainton Syndrome

Dysplasia, Cleidocranial
Hepatic Adenomas, Familial

Hepatic Adenoma, Somatic

Familial Hepatic Adenoma

Familial Liver Cell Adenomas

Liver Cell Adenomas, Familial

Hepatic Adenomas Familial

HEPAF

Ha

Hepatocellular Adenomas

Hepatocellular Adenoma
Malignant Giant Cell Tumor Of Soft Parts

Malignant Giant Cell Neoplasm Of Soft Parts
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14036 SUPT3H Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SUPT3H VGNC VGNC:46990
Bos taurus SUPT3H VGNC VGNC:35479
Mus musculus SUPT3H MGD MGI:1923723
Macaca mulatta SUPT3H VGNC VGNC:78055
Felis catus SUPT3H VGNC VGNC:65847
Rattus norvegicus SUPT3H RGD RGD:1591316
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