2. Gene
  3. INSM2 - INSM transcriptional repressor 2 Gene

INSM2 - INSM transcriptional repressor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：INSM 转录抑制因子 2

种属: Homo sapiens

同用名: IA6; IA-6; mlt1

基因 ID: 84684 | 基因类型: protein coding

关于 INSM2

Cytogenetic location: 14q13.2 Genomic coordinates (GRCh38): 14:35,534,164-35,537,054 (from NCBI)

This gene has 1 transcript (splice variant), 167 orthologues and 1 paralogue.

功能概要

预测可实现 DNA 结合转录抑制活性、RNA 聚合酶 II 特异性和 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。预计参与 RNA 聚合酶 II 对转录的负调控；神经元分化；和细胞周期过程的调节。预计位于细胞质中。预计是转录抑制复合物的一部分。预计活跃于核心。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; neuron differentiation; and regulation of cell cycle process. Predicted to be located in cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

INSM2 基因产物(1)

mRNA Protein Name
NM_032594.4 NP_115983.3 insulinoma-associated protein 2

INSM2 蛋白结构

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (291 - 313)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (426 - 448)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (470 - 491)

zf-C2H2_4

zf-C2H2_4: C2H2-type zinc finger (525 - 548)

  • 0
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  • 500
  • 566 a.a.
蛋白主名 其他名称

insulinoma-associated protein 2

insulinoma-associated 2

关联疾病

疾病名称 别名
Insulinoma

Islet Cell Adenoma

Insulin-Producing Tumor Of Islet Cells

Adenoma Islet Cell

Islet Cell Tumor

Experimental Organism Islet Cell Adenoma Neoplasm
Bleeding Disorder, Platelet-Type, 17

Platelet-Type Bleeding Disorder 17

BDPLT17

Thrombasthenia-Thrombocytopenia, Hereditary

Hereditary Thrombasthenia-Thrombocytopenia

Autosomal Dominant Macrothrombocytopenia Gfi1b-Related

Autosomal Dominant Platelet Disorder Gfi1b-Related

Bleeding Disorder, Platelet Type 17
Type 1 Diabetes Mellitus 5

Diabetes Mellitus, Insulin-Dependent, 5

Latent Autoimmune Diabetes In Adults

IDDM5

Insulin-Dependent Diabetes Mellitus 5

T1D5

Lada

Type 1.5 Diabetes

Diabetes Mellitus, Insulin-Dependent, Type 5
Type 1 Diabetes Mellitus 2

Diabetes Mellitus, Noninsulin-Dependent, 1

Diabetes Mellitus, Insulin-Dependent, 2

IDDM2

Insulin-Dependent Diabetes Mellitus 2

NIDDM1

Diabetes Mellitus, Noninsulin-Dependent 1

T1D2

Type 2 Diabetes Mellitus 1

T2D1

Noninsulin-Dependent Diabetes Mellitus 1

Diabetes Mellitus, Non-Insulin-Dependent, 1

Type 2 Diabetes Mellitus 1, Susceptibility To

Diabetes Mellitus, Insulin-Dependent, Type 2

Diabetes Mellitus, Non-Insulin-Dependent
Orthostatic Proteinuria

Postural Albuminuria
Arthrogryposis, Distal, Type 6

Distal Arthrogryposis Type 6

DA6

Arthrogryposis-Like Hand Anomaly-Sensorineural Deafness Syndrome

Arthrogryposis And Sensorineural Deafness

Familial Hand Abnormality And Sensori-Neural Deafness

Arthrogryposis-Like Hand Anomaly And Sensorineural Deafness

Arthrogryposis-Like Hand Anomaly-Sensorineural Hearing Loss Syndrome
Emphysematous Cholecystitis

Gaseous Pericholecystitis
Diabetes Mellitus, Ketosis-Prone

Diabetic Ketoacidosis

KPD

Diabetes Mellitus, Ketosis-Prone, Susceptibility To

Ketosis-Prone Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetic Ketoacidosis Nos

Dka - [Diabetic Ketoacidosis] Nos

Dka - [Diabetic Ketoacidosis] Without Coma

Dka - [Diabetic Ketoacidosis] With Coma
Maturity-Onset Diabetes Of The Young

MODY

Maturity Onset Diabetes Mellitus In Young

Mason-Type Diabetes

Mason Type Diabetes

Maturity Onset Diabetes Of The Young

Mody Syndrome

Diabetes Of The Young, Maturity-Onset
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06845 INSM2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22575 Insm2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29093 Insm2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus INSM2 VGNC VGNC:62934
Mus musculus INSM2 MGD MGI:1930787
Macaca mulatta INSM2 VGNC VGNC:73613
Rattus norvegicus INSM2 RGD RGD:1306949
Bos taurus INSM2 VGNC VGNC:106786
Canis familiaris INSM2 VGNC VGNC:42042
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