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  2. FCRLA - Fc receptor like A Gene

FCRLA - Fc receptor like A Gene

中文名称:Fc 受体样 A

种属: Homo sapiens

同用名: FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2

基因 ID: 84824 | 基因类型: protein coding

关于 FCRLA

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:161,707,229-161,714,352 (from NCBI)

This gene has 16 transcripts (splice variants), 209 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 32.1), spleen (RPKM 21.2) and 3 other tissues.

功能概要

该基因编码的蛋白质类似于γ免疫球蛋白 (IgG) Fc 片段的受体。这些称为 FCGR 的受体介导 IgG 包被的抗原和抗体诱导的细胞的破坏。这种编码的蛋白质在 B 细胞中选择性表达,并可能参与它们的发育。这种蛋白质也可能参与淋巴瘤的发展。已针对该基因描述了编码不同蛋白质亚型的多个可变剪接转录物变体。[RefSeq 提供,2011 年 8 月]

This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

FCRLA 基因产物(9)

mRNA Protein Name
NM_001184866.2 NP_001171795.2 Fc receptor-like A isoform 1 precursor
NM_001184867.2 NP_001171796.2 Fc receptor-like A isoform 3 precursor
NM_001184870.2 NP_001171799.2 Fc receptor-like A isoform 4 precursor
NM_001184871.2 NP_001171800.2 Fc receptor-like A isoform 7 precursor
NM_001184872.2 NP_001171801.2 Fc receptor-like A isoform 5
NM_001184873.2 NP_001171802.2 Fc receptor-like A isoform 6 precursor
NM_001366195.2 NP_001353124.2 Fc receptor-like A isoform 8 precursor
NM_001366196.2 NP_001353125.2 Fc receptor-like A isoform 9 precursor
NM_032738.4 NP_116127.4 Fc receptor-like A isoform 2 precursor

FCRLA 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (103 - 174)

Ig_2

Ig_2: Immunoglobulin domain (194 - 283)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
蛋白主名 其他名称

Fc receptor-like A

Fc receptor homolog expressed in B cells (FREB)

关联疾病

疾病名称 别名
Melanoma

Malignant Melanoma

Cutaneous Melanoma

Naevocarcinoma

Malignant Melanomas

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus FCRLA RGD RGD:1306176
Felis catus FCRLA VGNC VGNC:62217
Mus musculus FCRLA MGD MGI:2138647
Canis familiaris FCRLA VGNC VGNC:40810
Bos taurus FCRLA VGNC VGNC:28939
Macaca mulatta FCRLA VGNC VGNC:72526