2. Gene
  3. DGKD - diacylglycerol kinase delta Gene

DGKD - diacylglycerol kinase delta Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：二酰甘油激酶δ

种属: Homo sapiens

同用名: dgkd-2; DGKdelta; DGK-delta

基因 ID: 8527 | 基因类型: protein coding

关于 DGKD

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,354,494-233,472,098 (from NCBI)

This gene has 14 transcripts (splice variants), 1 gene allele, 213 orthologues and 9 paralogues. Broad expression in stomach (RPKM 11.9), bone marrow (RPKM 9.9) and 23 other tissues.

功能概要

该基因编码一种细胞质酶，可使二酰基甘油磷酸化以产生磷脂酸。二酰甘油和磷脂酸是在信号级联中充当第二信使的两种脂质。它们的细胞浓度由编码的蛋白质调节，因此被认为在细胞信号转导中发挥重要作用。可变剪接导致编码不同异构体的两个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

DGKD 基因产物(3)

mRNA Protein Name
NM_001377259.1 NP_001364188.1 diacylglycerol kinase delta isoform 3
NM_003648.3 NP_003639.2 diacylglycerol kinase delta isoform 1
NM_152879.3 NP_690618.2 diacylglycerol kinase delta isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP-dependent diacylglycerol kinase activity IDA
IDA: 通过直接分析推断
12200442 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
12084710 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12200442 GOA
enables kinase binding IPI
IPI: 通过物理相互作用推断
12810723 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12200442 GOA
enables protein heterodimerization activity IDA
IDA: 通过直接分析推断
12200442 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
12200442 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in diacylglycerol metabolic process IDA
IDA: 通过直接分析推断
12200442 GOA
involved in lipid phosphorylation IDA
IDA: 通过直接分析推断
17880279 GOA
involved in phosphatidic acid biosynthetic process IDA
IDA: 通过直接分析推断
17880279 GOA
involved in positive regulation of clathrin-dependent endocytosis IMP
IMP: 通过突变表型推断
17880279 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in clathrin-coated pit IDA
IDA: 通过直接分析推断
17880279 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
12200442 GOA
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
12200442 GOA
located in cytosol IDA
IDA: 通过直接分析推断
12084710 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12084710 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DGKD 蛋白结构

PH

PH: PH domain (54 - 144)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (164 - 214)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (236 - 287)

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (321 - 446)

DAGK_acc

DAGK_acc: Diacylglycerol kinase accessory domain (763 - 920)

SAM_2

SAM_2: SAM domain (Sterile alpha motif) (1142 - 1205)

  • 0
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  • 1214 a.a.
蛋白主名 其他名称

diacylglycerol kinase delta

DAG kinase delta

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03717 DGKD Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DGKD VGNC VGNC:39917
Macaca mulatta DGKD VGNC VGNC:71783
Bos taurus DGKD VGNC VGNC:28026
Rattus norvegicus DGKD RGD RGD:1563309
Mus musculus DGKD MGD MGI:2138334
Felis catus DGKD VGNC VGNC:61459
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