2. Gene
  3. Shc1 - SHC adaptor protein 1 Gene

Shc1 - SHC adaptor protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: P66shc

基因 ID: 85385 | 基因类型: protein coding

关于 Shc1

功能概要

Enables enzyme binding activity; epidermal growth factor receptor binding activity; and phosphotyrosine residue binding activity. Involved in several processes, including positive regulation of smooth muscle cell proliferation; positive regulation of vasoconstriction; and response to peptide hormone. Located in endosome membrane; nucleus; and plasma membrane. Part of Shc-EGFR complex. Used to study glomerulosclerosis. Biomarker of familial hyperlipidemia and hepatocellular carcinoma. Orthologous to human SHC1 (SHC adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Shc1 基因产物(2)

mRNA Protein Name
NM_001164060.2 NP_001157532.1 SHC-transforming protein 1 isoform a
NM_053517.3 NP_445969.2 SHC-transforming protein 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables epidermal growth factor receptor binding IPI
IPI: 通过物理相互作用推断
7513704 RGD
enables phosphoprotein binding IPI
IPI: 通过物理相互作用推断
8910399 RGD
enables phosphotyrosine residue binding IPI
IPI: 通过物理相互作用推断
9271418 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
11694516 RGD
enables protein phosphatase 2A binding IDA
IDA: 通过直接分析推断
11884620 RGD
enables protein phosphatase 2A binding IPI
IPI: 通过物理相互作用推断
11884620 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
11884620 RGD
enables receptor tyrosine kinase binding IPI
IPI: 通过物理相互作用推断
9582017 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IMP
IMP: 通过突变表型推断
15262993 RGD
involved in animal organ regeneration IEP
IEP: 通过表达模式推断
15067377 RGD
involved in cellular response to insulin stimulus IEP
IEP: 通过表达模式推断
11884620 RGD
involved in insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
17925406 RGD
involved in insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
7513704 RGD
involved in neuron differentiation IMP
IMP: 通过突变表型推断
17274988 RGD
involved in neuron projection development IMP
IMP: 通过突变表型推断
15485499 RGD
involved in positive regulation of MAPK cascade IMP
IMP: 通过突变表型推断
15262993 RGD
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
7513704 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
12837289 RGD
involved in positive regulation of vasoconstriction IMP
IMP: 通过突变表型推断
16242150 RGD
involved in regulation of smooth muscle contraction IMP
IMP: 通过突变表型推断
27270176 RGD
involved in response to endothelin IMP
IMP: 通过突变表型推断
27270176 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
10612430 RGD
involved in response to hydrogen peroxide IEP
IEP: 通过表达模式推断
16699171 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
16439820 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
11954667 RGD
involved in response to nicotine IEP
IEP: 通过表达模式推断
17068140 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
16699171 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
16699171 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of Shc-EGFR complex IDA
IDA: 通过直接分析推断
7513704 RGD
located in endosome membrane IDA
IDA: 通过直接分析推断
17363458 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

SHC-transforming protein 1

SH2 domain protein C1

SHC (Src homology 2 domain containing) transforming protein 1

src homology 2 domain-containing-transforming protein C1

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12856 SHC1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS21432 Shc1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS27950 Shc1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Shc1 NCBI NCBI:6464
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