1. Gene
  2. SLC22A16 - solute carrier family 22 member 16 Gene

SLC22A16 - solute carrier family 22 member 16 Gene

中文名称:溶质载体家族 22 成员 16

种属: Homo sapiens

同用名: CT2; OAT6; OCT6; OKB1; FLIPT2; HEL-S-18; dJ261K5.1

基因 ID: 85413 | 基因类型: protein coding

关于 SLC22A16

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,424,687-110,476,613 (from NCBI)

This gene has 8 transcripts (splice variants), 258 orthologues and 22 paralogues. Biased expression in testis (RPKM 7.7) and bone marrow (RPKM 4.9).

功能概要

该基因编码转运肉毒碱的有机两性离子转运蛋白家族的成员。编码的蛋白质也被证明可以运输抗癌药物,如博来霉素 (PMID:20037140) ,成功的治疗与肿瘤细胞中这种转运蛋白的活性水平相关。[RefSeq 提供,2011 年 12 月]

This gene encodes a member of the organic zwitterion transporter protein family which transports carnitine. The encoded protein has also been shown to transport Anticancer drugs like bleomycin (PMID: 20037140) successful treatment has been correlated with the level of activity of this transporter in tumor cells. [provided by RefSeq, Dec 2011]

SLC22A16 基因产物(1)

mRNA Protein Name
NM_033125.4 NP_149116.2 solute carrier family 22 member 16
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables amine transmembrane transporter activity IDA
IDA: 通过直接分析推断
15963465 GOA
enables carnitine transmembrane transporter activity IDA
IDA: 通过直接分析推断
12089149 GOA
enables organic cation transmembrane transporter activity IDA
IDA: 通过直接分析推断
12089149 GOA
enables spermidine transmembrane transporter activity IDA
IDA: 通过直接分析推断
20037140 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acid secretion IDA
IDA: 通过直接分析推断
12089149 GOA
involved in carnitine transmembrane transport IDA
IDA: 通过直接分析推断
12089149 GOA
acts upstream of or within carnitine transport IDA
IDA: 通过直接分析推断
12089149 GOA
involved in carnitine transport IDA
IDA: 通过直接分析推断
12089149 GOA
involved in flagellated sperm motility IMP
IMP: 通过突变表型推断
12089149 GOA
acts upstream of or within organic cation transport IDA
IDA: 通过直接分析推断
15963465 GOA
involved in organic cation transport IDA
IDA: 通过直接分析推断
12089149 GOA
involved in single fertilization IMP
IMP: 通过突变表型推断
12089149 GOA
involved in spermidine transmembrane transport IDA
IDA: 通过直接分析推断
20037140 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
12089149 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12089149 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SLC22A16 蛋白结构

Sugar_tr

Sugar_tr: Sugar (and other) transporter (150 - 533)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 577 a.a.
蛋白主名 其他名称

solute carrier family 22 member 16

WUGSC:RG331P03.1

关联疾病

疾病名称 别名
Clear Cell Adenocarcinoma

Mesonephroma

Water-Clear Cell Adenocarcinoma

Adenocarcinoma, Clear Cell

Malignant Mesonephroma

Mesonephroid Clear Cell Carcinoma

Mesonephroma, Malignant

Water-Clear Cell Carcinoma

Wolffian Duct Neoplasm

Adenocarcinoma Clear Cell

Mesonephric Tumor

Rhizomelic Chondrodysplasia Punctata, Type 3

Rhizomelic Chondrodysplasia Punctata Type 3

RCDP3

Alkyldihydroxyacetonephosphate Synthase Deficiency

Alkylglycerone-Phosphate Synthase Deficiency

Agps Deficiency

Rhizomelic Chondrodysplasia Punctata 3

Chondrodysplasia Punctata, Rhizomelic, Type 3

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Cancer Of The Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SLC22A16 VGNC VGNC:65241
Rattus norvegicus SLC22A16 RGD RGD:1592810
Macaca mulatta SLC22A16 VGNC VGNC:77527
Bos taurus SLC22A16 VGNC VGNC:34724
Mus musculus SLC22A16 MGD MGI:1918090
Canis familiaris SLC22A16 VGNC VGNC:46277