2. Gene
  3. SCIN - scinderin Gene

SCIN - scinderin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：辛德林

种属: Homo sapiens

基因 ID: 85477 | 基因类型: protein coding

关于 SCIN

Cytogenetic location: 7p21.3 Genomic coordinates (GRCh38): 7:12,570,720-12,660,182 (from NCBI)

This gene has 10 transcripts (splice variants), 179 orthologues and 7 paralogues. Biased expression in small intestine (RPKM 29.7), kidney (RPKM 29.3) and 11 other tissues.

功能概要

SCIN 是一种 CA (2+) 依赖性肌动蛋白切断和加帽蛋白 (Zunino 等人，2001 [PubMed 11568009]) 。[OMIM 提供，2010 年 5 月]

SCIN is a CA(2+)-dependent actin-severing and -capping protein (Zunino et al., 2001 [PubMed 11568009]).[supplied by OMIM, May 2010]

SCIN 基因产物(2)

mRNA Protein Name
NM_001112706.3 NP_001106177.1 scinderin isoform 1
NM_033128.3 NP_149119.1 scinderin isoform 2
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin filament capping IMP
IMP: 通过突变表型推断
19666531 GOA
involved in actin filament severing IMP
IMP: 通过突变表型推断
11568009 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
11568009 GOA
involved in positive regulation of actin nucleation IMP
IMP: 通过突变表型推断
19666531 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
11568009 GOA
involved in positive regulation of megakaryocyte differentiation IMP
IMP: 通过突变表型推断
11568009 GOA
involved in sequestering of actin monomers IMP
IMP: 通过突变表型推断
19666531 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SCIN 蛋白结构

Gelsolin

Gelsolin: Gelsolin repeat (28 - 107)

Gelsolin

Gelsolin: Gelsolin repeat (148 - 220)

Gelsolin

Gelsolin: Gelsolin repeat (265 - 340)

Gelsolin

Gelsolin: Gelsolin repeat (410 - 482)

Gelsolin

Gelsolin: Gelsolin repeat (526 - 590)

Gelsolin

Gelsolin: Gelsolin repeat (629 - 703)

  • 0
  • 200
  • 400
  • 600
  • 715 a.a.
蛋白主名 其他名称

scinderin

adseverin

SCIN 抗体

目录号 产品名 应用 反应物种
HY-P82166 SCIN Antibody (YA1911) WB, IHC-P Human

关联疾病

疾病名称 别名
Ritter'S Disease

Staphylococcal Scalded Skin Syndrome

Pemphigus Neonatorum

Ritter Disease

Dermatitis Exfoliativa Neonatorum

Scalded Skin Syndrome

Toxic Epidermal Necrolysis, Subcorneal Type

Generalized Exfoliative Disease

Ssss

Ssss - [Staphylococcal Scalded Skin Syndrome]
Carbuncle

Carbuncle And Furuncle Of Any Part Of Face Except Eye

Carbuncle And Furuncle Of Buttock

Carbuncle And Furuncle Of Face

Carbuncle And Furuncle Of Foot

Carbuncle And Furuncle Of Gluteal Region

Carbuncle And Furuncle Of Hand

Carbuncle And Furuncle Of Leg Except Foot

Carbuncle And Furuncle Of Neck

Carbuncle And Furuncle Of Trunk

Carbuncle And Furuncle Of Upper Arm And Forearm
Endocardium Disease
Septic Arthritis

Infectious Arthritis

Arthritis, Infectious

Arthritis Septic

Arthritis, Bacterial
Waterhouse-Friderichsen Syndrome

Fatal Pneumococcal Waterhouse-Friderichsen Syndrome

Meningococcal Hemorrhagic Adrenalitis

Waterhouse-Friderichsen Syndrome, Meningococcal

Meningococcal Haemorrhagic Adrenalitis

Meningococcal Adrenal Syndrome

Acute Adrenal Insufficiency With Meningococcal Septicaemia

Adrenal Haemorrhage Syndrome

Waterhouse-Friderichsen Disease

Meningococcal Waterhouse-Friderichsen Syndrome

Haemorrhagic Meningococcal Adrenitis
Commensal Bacterial Infectious Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12512 SCIN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17695 Scin Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24157 Scin Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus SCIN VGNC VGNC:34339
Felis catus SCIN VGNC VGNC:64914
Mus musculus SCIN MGD MGI:1306794
Macaca mulatta SCIN VGNC VGNC:81562
Rattus norvegicus SCIN RGD RGD:735034
Others SCIN NCBI
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