1. Gene
  2. AOC3 - amine oxidase copper containing 3 Gene

AOC3 - amine oxidase copper containing 3 Gene

中文名称:含铜胺氧化酶 3

种属: Homo sapiens

同用名: HPAO; SSAO; VAP1; VAP-1

基因 ID: 8639 | 基因类型: protein coding

关于 AOC3

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:42,851,199-42,858,124 (from NCBI)

This gene has 7 transcripts (splice variants), 312 orthologues and 2 paralogues. Biased expression in fat (RPKM 252.0), lung (RPKM 69.7) and 8 other tissues.

功能概要

该基因编码氨基脲敏感胺氧化酶家族的成员。铜胺氧化酶在铜和醌辅助因子存在下催化胺氧化转化为醛。编码的蛋白质定位于细胞表面,具有粘附特性以及单胺氧化酶活性,并且可能参与白细胞运输。编码蛋白水平的改变可能与许多疾病有关,包括糖尿病。该基因的假基因已被描述,位于同一染色体下游约 9-kb 处。可变剪接导致多个转录本变体。[RefSeq 提供,2013 年 4 月]

This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as Monoamine Oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]

AOC3 基因产物(3)

mRNA Protein Name
NM_001277731.2 NP_001264660.1 membrane primary amine oxidase isoform 2
NM_001277732.2 NP_001264661.1 membrane primary amine oxidase isoform 3
NM_003734.4 NP_003725.1 membrane primary amine oxidase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
16046623 GOA
enables copper ion binding IDA
IDA: 通过直接分析推断
16046623 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16046623 GOA
NOT enables primary methylamine oxidase activity IDA
IDA: 通过直接分析推断
23349812 GOA
enables primary methylamine oxidase activity IDA
IDA: 通过直接分析推断
9653080 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23349812 GOA
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
23349812 GOA
enables quinone binding IDA
IDA: 通过直接分析推断
9653080 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amine metabolic process IDA
IDA: 通过直接分析推断
9653080 GOA
involved in cell adhesion IDA
IDA: 通过直接分析推断
9653080 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
23474851 GOA
located in cell surface IDA
IDA: 通过直接分析推断
9653080 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
23349812 GOA
located in early endosome IDA
IDA: 通过直接分析推断
23474851 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
23474851 GOA
located in membrane IDA
IDA: 通过直接分析推断
9653080 GOA
located in microvillus IDA
IDA: 通过直接分析推断
23349812 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
9653080 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

AOC3 蛋白结构

Cu_amine_oxidN2

Cu_amine_oxidN2: Copper amine oxidase, N2 domain (66 - 152)

Cu_amine_oxidN3

Cu_amine_oxidN3: Copper amine oxidase, N3 domain (169 - 268)

Cu_amine_oxid

Cu_amine_oxid: Copper amine oxidase, enzyme domain (313 - 722)

  • 0
  • 200
  • 400
  • 600
  • 763 a.a.
蛋白主名 其他名称

membrane primary amine oxidase

amine oxidase, copper containing 3 (vascular adhesion protein 1)

AOC3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
AOC3 Q16853 ARL13B Homo sapiens Q3SXY8 32296183
种属内
AOC3 Q16853 ARL13B Homo sapiens Q3SXY8 32296183
种属内
AOC3 Q16853 ARL13B Homo sapiens Q3SXY8 32296183
种属内
AOC3 Q16853 FNDC9 Homo sapiens Q8TBE3 32296183
种属内
AOC3 Q16853 FNDC9 Homo sapiens Q8TBE3 32296183
种属内
AOC3 Q16853 FNDC9 Homo sapiens Q8TBE3 32296183
种属内
AOC3 Q16853 CPLX4 Homo sapiens Q7Z7G2 32296183
种属内
AOC3 Q16853 CPLX4 Homo sapiens Q7Z7G2 32296183
种属内
AOC3 Q16853 CPLX4 Homo sapiens Q7Z7G2 32296183
种属内
AOC3 Q16853 HSD17B13 Homo sapiens Q7Z5P4 32296183
种属内
AOC3 Q16853 HSD17B13 Homo sapiens Q7Z5P4 32296183
种属内
AOC3 Q16853 HSD17B13 Homo sapiens Q7Z5P4 32296183
种属内
AOC3 Q16853 CLDN9 Homo sapiens O95484 32296183
种属内
AOC3 Q16853 CLDN9 Homo sapiens O95484 32296183
种属内
AOC3 Q16853 SGTA Homo sapiens O43765 32296183
种属内
AOC3 Q16853 SGTA Homo sapiens O43765 32296183
种属内
AOC3 Q16853 DARS2 Homo sapiens Q6PI48 32296183
种属内
AOC3 Q16853 DARS2 Homo sapiens Q6PI48 32296183
种属内
AOC3 Q16853 DARS2 Homo sapiens Q6PI48 32296183
种属内
AOC3 Q16853 CREB3L1 Homo sapiens Q96BA8 32296183
种属内
AOC3 Q16853 CREB3L1 Homo sapiens Q96BA8 32296183
种属内
AOC3 Q16853 CREB3L1 Homo sapiens Q96BA8 32296183
种属内
AOC3 Q16853 STX1A Homo sapiens Q16623 32296183
种属内
AOC3 Q16853 STX1A Homo sapiens Q16623 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 AOC3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70065 AOC3 Protein, Human (HEK293, His) Q16853 (R28-N763) ≥95%

关联疾病

疾病名称 别名
Diabetic Angiopathy

Diabetic Angiopathies

Diabetic Peripheral Angiopathy

Diabetic Vascular Disorder

Diabetes Mellitus

Diabetes

Congestive Heart Failure

Congestive Heart Disease

Heart Failure

Cardiac Failure Congestive

Chf

Weak Heart

Heart Failure Congestive

Ccf - [Congestive Cardiac Failure]

Chf - [Congestive Heart Failure]

Congestive Cardiac Diseases

Congested Heart Failure

Congestive Cardiac Failure

Cardiac Anasarca

Cardiac Oedema

Cardiac Stasis

Cardiovascular Oedema

Cardiac Hydrops

Congestive Failure

Heart Congestion

Heart Fluid

Oedematous Heart

Type 1 Diabetes Mellitus 23

Diabetes Mellitus, Insulin-Dependent, 23

Iddm23

T1D23

Insulin-Dependent Diabetes Mellitus 23

Immunodeficiency 17

IMD17

Cd3-Gamma Deficiency

Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive

Combined Immunodeficiency Due To Cd3gamma Deficiency

Immunodeficiency 17, Cd3 Gamma Deficient

Cd3gamma Deficiency

Immunodeficiency, Type 17

Cerebral Amyloid Angiopathy, Cst3-Related

Cerebral Amyloid Angiopathy

Hereditary Cerebral Hemorrhage With Amyloidosis

Hchwa

Hereditary Cystatin C Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Familial

Amyloidosis, Cerebroarterial, Icelandic Type

Amyloidosis Vi

Cerebral Hemorrhage, Hereditary, With Amyloidosis

Cst3-Related Cerebral Amyloid Angiopathy

Cerebral Hemorrhage, Hereditary, With Amyloidosis, Icelandic Variant

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Variant

Caa, Familial

Cerebral Amyloid Angiopathy, Genetic

Acys Amyloidosis

Cst3-Related Amyloidosis

Cystatin Amyloidosis

Hchwa, Icelandic Type

Hereditary Cerebral Hemorrhage With Amyloidosis, Icelandic Type

Amyloidosis 6

AMYL6

Acys

Caa

Cerebral Amyloid Angiopathy Cst3-Related

Cerebroarterial Amyloidosis Icelandic Type

Cystatin C Amyloidosis

Hccaa

Hchwai

Hchwa-I

Hereditary Cerebral Hemorrhage With Amyloidosis Icelandic Type

Cerebral Amyloid Angiopathy Familial

Angiopathy, Amyloid, Cerebral, Cst3-Related

Hereditary Cerebral Amyloid Angiopathy, Icelandic Type

Familial Cerebral Amyloid Angiopathy

Cerebral Amyloid Angiopathy, Hereditary

Miyoshi Muscular Dystrophy 3

MMD3

Miyoshi Myopathy 3

Distal Anoctaminopathy

Miyoshi Muscular Dystrophy Type 3

Dystrophy, Muscular, Miyoshi, Type 3

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent

Diabetes Mellitus Type 1

IDDM

Type 1 Diabetes

Insulin-Dependent Diabetes Mellitus

T1D

Juvenile-Onset Diabetes

Jod

Diabetes Mellitus, Type 1

Diabetes Mellitus, Insulin-Dependent-1

Type I Diabetes Mellitus

Autoimmune Diabetes

Juvenile Diabetes

Juvenile-Onset Diabetes Mellitus

Diabetes, Insulin Dependent

Insulin-Dependent Diabetes Mellitus-1

Diabetes Mellitus Insulin-Dependent

Diabetes Autoimmune

Diabetes Mellitus, Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 1, Susceptibility To

Diabetes Type 1

Type I Diabetes

Diabetes, Autoimmune

T1dm - [Type 1 Diabetes Mellitus]

Iddm - [Insulin Dependent Diabetes Mellitus]

Type 1 Iddm

Juvenile Diabetes Mellitus Without Compications

Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications

Juvenile-Onset Diabetes Mellitus Without Compications

Ketosis-Prone Diabetes Mellitus Without Compications

Juvenile-Onset-Type Diabetes Mellitus Without Compications

Microvascular Complications Of Diabetes 5

Diabetic Retinopathy

Microvascular Complications Of Diabetes, Susceptibility To, 5

MVCD5

Retinopathy, Diabetic

Diabetic Nephropathy

Retinopathy, Diabetic, Susceptibility To

Retinal Abnormality - Diabetes-Related

Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Dermatitis, Atopic, 7

ATOD7

Dermatitis, Atopic, Susceptibility To, 7

Atopic Dermatitis 7

Dermatitis, Atopic 7

Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8

Iddm8

Insulin-Dependent Diabetes Mellitus 8

T1D8

Insulin-Dependent Diabetes Mellitus-8

Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

Cholangitis, Primary Sclerosing

Primary Sclerosing Cholangitis

PSC

Sclerosing Cholangitis

Cholangitis, Sclerosing

Cholangitis Primary Sclerosing

Psc - [Primary Sclerosing Cholangitis]

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus AOC3 RGD RGD:62058
Canis familiaris AOC3 VGNC VGNC:37949
Mus musculus AOC3 MGD MGI:1306797
Others AOC3 NCBI