2. Gene
  3. ADAM18 - ADAM metallopeptidase domain 18 Gene

ADAM18 - ADAM metallopeptidase domain 18 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ADAM 金属肽酶结构域 18

种属: Homo sapiens

同用名: ADAM27; tMDCIII

基因 ID: 8749 | 基因类型: protein coding

关于 ADAM18

Cytogenetic location: 8p11.22 Genomic coordinates (GRCh38): 8:39,584,568-39,730,065 (from NCBI)

This gene has 8 transcripts (splice variants), 1 gene allele, 357 orthologues and 20 paralogues. Restricted expression toward testis (RPKM 6.7).

功能概要

该基因编码 ADAM (一种去整合素和金属蛋白酶结构域) 家族的成员。该家族的成员是膜锚定蛋白，在结构上与蛇毒解离蛋白相关，并且涉及涉及细胞-细胞和细胞-基质相互作用的各种生物过程，包括受精、肌肉发育和神经发生。编码的前原蛋白经过蛋白水解处理以产生成熟的精子表面蛋白。可变剪接导致多个转录本变体，其中至少一个编码一种经过蛋白水解处理的亚型。[RefSeq 提供，2016 年 2 月]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

ADAM18 基因产物(3)

mRNA Protein Name
NM_001190956.2 NP_001177885.1 disintegrin and metalloproteinase domain-containing protein 18 isoform 2 precursor
NM_001320313.2 NP_001307242.1 disintegrin and metalloproteinase domain-containing protein 18 isoform 3 precursor
NM_014237.3 NP_055052.1 disintegrin and metalloproteinase domain-containing protein 18 isoform 1 preproprotein

ADAM18 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (29 - 141)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (184 - 379)

Disintegrin

Disintegrin: Disintegrin (399 - 476)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (479 - 589)

  • 0
  • 200
  • 400
  • 600
  • 739 a.a.
蛋白主名 其他名称

disintegrin and metalloproteinase domain-containing protein 18

a disintegrin and metalloproteinase domain 18

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-17377 Vicriviroc maleate 99.91% Phase 3
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00271 ADAM17 Human Pre-designed siRNA Set A / 否
HY-RS00274 ADAM18 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ADAM18 VGNC VGNC:55028
Macaca mulatta ADAM18 VGNC VGNC:83975
Rattus norvegicus ADAM18 RGD RGD:620405
Canis familiaris ADAM18 VGNC VGNC:49740
Mus musculus ADAM18 MGD MGI:105986
Others ADAM18 NCBI
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