CDK5R1 - cyclin dependent kinase 5 regulatory subunit 1 Gene

中文名称：细胞周期蛋白依赖性激酶 5 调节亚基 1

种属: Homo sapiens

同用名: p23; p25; p35; CDK5R; NCK5A; CDK5P35; p35nck5a

关于 CDK5R1

功能概要

该基因 (p35) 编码的蛋白质是细胞周期蛋白依赖性激酶 5 (CDK5) 的神经元特异性激活剂； CDK5 的激活是中枢神经系统正常发育所必需的。这种蛋白质的 p35 形式被钙蛋白酶蛋白水解切割，产生 p25 形式。 p35 裂解成 p25 导致蛋白质从细胞外周重新定位到核和核周区域。 P25 通过延长其激活和改变其细胞位置来解除对 CDK5 活性的调节。 p25 形式在阿尔茨海默病患者的大脑神经元中积累。这种积累与 CDK5 激酶活性的增加相关，并可能导致微管相关蛋白 tau 的异常磷酸化形式，从而导致阿尔茨海默病。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]