2. Gene
  3. ABCC10 - ATP binding cassette subfamily C member 10 Gene

ABCC10 - ATP binding cassette subfamily C member 10 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ATP 结合盒亚家族 C 成员 10

种属: Homo sapiens

同用名: MRP7; SIMRP7; EST182763

基因 ID: 89845 | 基因类型: protein coding

关于 ABCC10

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:43,427,541-43,451,994 (from NCBI)

This gene has 10 transcripts (splice variants), 480 orthologues and 11 paralogues. Ubiquitous expression in ovary (RPKM 3.1), spleen (RPKM 3.0) and 25 other tissues.

功能概要

由该基因编码的蛋白质是 ATP 结合盒 (ABC) 转运蛋白超家族的成员。 ABC 蛋白可跨细胞外膜和细胞内膜转运各种分子。 ABC 基因分为七个不同的亚家族 (ABC1、MDR/TAP、MRP、ALD、OABP、GCN20 和 White) 。这种 ABC 全转运蛋白是参与多重耐药性的 MRP 亚家族的成员。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2010 年 11 月]

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Nov 2010]

ABCC10 基因产物(3)

mRNA Protein Name
NM_001198934.2 NP_001185863.1 ATP-binding cassette sub-family C member 10 isoform MRP7
NM_001350518.2 NP_001337447.1 ATP-binding cassette sub-family C member 10 isoform 3
NM_033450.3 NP_258261.2 ATP-binding cassette sub-family C member 10 isoform MRP7A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ABC-type glutathione S-conjugate transporter activity IDA
IDA: 通过直接分析推断
23087055 GOA
enables ABC-type transporter activity IDA
IDA: 通过直接分析推断
23087055 GOA
enables ABC-type xenobiotic transporter activity IDA
IDA: 通过直接分析推断
23087055 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in leukotriene metabolic process IDA
IDA: 通过直接分析推断
23087055 GOA
involved in leukotriene transport IDA
IDA: 通过直接分析推断
23087055 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in basal plasma membrane IDA
IDA: 通过直接分析推断
35307651 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
23087055 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
28112518 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ABCC10 蛋白结构

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (286 - 551)

ABC_tran

ABC_tran: ABC transporter (620 - 753)

ABC_membrane

ABC_membrane: ABC transporter transmembrane region (958 - 1197)

ABC_tran

ABC_tran: ABC transporter (1263 - 1410)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1492 a.a.
蛋白主名 其他名称

ATP-binding cassette sub-family C member 10

ATP-binding cassette, sub-family C (CFTR/MRP), member 10

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00058 ABCC10 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ABCC10 RGD RGD:1306696
Bos taurus ABCC10 VGNC VGNC:25469
Canis familiaris ABCC10 VGNC VGNC:37437
Mus musculus ABCC10 MGD MGI:2386976
Felis catus ABCC10 VGNC VGNC:67653
Macaca mulatta ABCC10 VGNC VGNC:81005
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