NOL3 - nucleolar protein 3 Gene

中文名称：核仁蛋白 3

种属: Homo sapiens

同用名: ARC; FCM; MYP; NOP; NOP30; MYOCL1

基因 ID: 8996 | 基因类型: protein coding

关于 NOL3

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,170,538-67,175,737 (from NCBI)

This gene has 13 transcripts (splice variants), 89 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in skin (RPKM 15.7), prostate (RPKM 15.6) and 24 other tissues.

功能概要

该基因编码一种抗凋亡蛋白，该蛋白已被证明可下调半胱天冬酶 2、半胱天冬酶 8 和肿瘤蛋白 p53 的酶活性。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2010 年 6 月]

This gene encodes an anti-apoptotic protein that has been shown to down-regulate the enzyme activities of Caspase 2, Caspase 8 and tumor protein p53. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

NOL3 基因产物(13)

mRNA	Protein	Name
NM_001185057.3	NP_001171986.1	nucleolar protein 3 isoform Nop30
NM_001276307.3	NP_001263236.1	nucleolar protein 3 isoform MYP
NM_001276309.3	NP_001263238.1	nucleolar protein 3 isoform MYP
NM_001276311.2	NP_001263240.1	nucleolar protein 3 isoform C
NM_001276312.3	NP_001263241.1	nucleolar protein 3 isoform MYP
NM_001394973.1	NP_001381902.1	nucleolar protein 3 isoform MYP
NM_001394974.1	NP_001381903.1	nucleolar protein 3 isoform C
NM_001394975.1	NP_001381904.1	nucleolar protein 3 isoform C
NM_001394976.1	NP_001381905.1	nucleolar protein 3 isoform C
NM_001394977.1	NP_001381906.1	nucleolar protein 3 isoform Nop30
NM_001394978.1	NP_001381907.1	nucleolar protein 3 isoform Nop30
NM_001394979.1	NP_001381908.1	nucleolar protein 3 isoform E
NM_003946.7	NP_003937.1	nucleolar protein 3 isoform MYP

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium ion binding	IMP IMP: 通过突变表型推断	15509781	GOA
enables caspase binding	IPI IPI: 通过物理相互作用推断	9560245	GOA
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: 通过直接分析推断	9560245	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	10196175	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in inhibition of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: 通过直接分析推断	15509781	GOA
involved in mRNA splice site recognition	IDA IDA: 通过直接分析推断	10196175	GOA
involved in negative regulation of apoptotic process	IMP IMP: 通过突变表型推断	15509781	GOA
involved in negative regulation of extrinsic apoptotic signaling pathway	IDA IDA: 通过直接分析推断	9560245	GOA
involved in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IDA IDA: 通过直接分析推断	15004034	GOA
involved in negative regulation of release of cytochrome c from mitochondria	IDA IDA: 通过直接分析推断	15004034	GOA
involved in protein complex oligomerization	IDA IDA: 通过直接分析推断	10196175	GOA
involved in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA IDA: 通过直接分析推断	15509781	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10196175	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	10196175	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOL3 蛋白结构

CARD

0
100
208 a.a.

蛋白主名

其他名称

nucleolar protein 3

muscle-enriched cytoplasmic protein

NOL3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	NOL3	O60936	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
种属内	NOL3	O60936	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
种属内	NOL3	O60936	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
种属内	NOL3	O60936	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
种属内	NOL3	O60936	ETNK2	Homo sapiens	Q9NVF9	Y2H Pooling	16189514
种属内	NOL3	O60936	NOL3	Homo sapiens	O60936	Y2H Pooling	16189514
种属内	NOL3	O60936	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183
种属内	NOL3	O60936	POT1	Homo sapiens	Q9NUX5	BiFC	21044950
种属内	NOL3	O60936	CASP8	Homo sapiens	Q14790	Anti Tag CoIP	18245485
种属内	NOL3	O60936	NIF3L1	Homo sapiens	Q9GZT8	Y2H Pooling	16189514
种属内	NOL3	O60936	CASP8	Homo sapiens	Q14790	Anti Bait CoIP	18245485
种属内	NOL3	O60936	NOL3	Homo sapiens	O60936	Pull Down	16189514
种属内	NOL3	O60936	SIRPA	Homo sapiens	P78324	Y2H Pooling	16189514

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NOL3 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7540	ARC Protein, Human	O60936 (M1-S208)	≥95%

关联疾病

疾病名称

别名

Myoclonus, Familial, 1

Myoclonus, Familial Cortical	MYOCL1
Fcm	Familial Cortical Myoclonus

Myoclonus

Ischemia

Acute Coronary Syndrome

Ulcerative Stomatitis

Stomatitis Ulcerative	Aphthous Stomatitis
Minor Oral Aphthous Ulceration

Familial Adult Myoclonic Epilepsy

Benign Adult Familial Myoclonus Epilepsy	Bafme
Benign Adult Familial Myoclonic Epilepsy	Fame
Familial Cortical Myoclonic Tremor And Epilepsy	Fcmte
Adcme	Autosomal Dominant Cortical Myoclonus And Epilepsy
Fam	Epilepsy, Myoclonic, Familial Adult
Epilepsy, Myoclonic, Benign Adult Familial, Type 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09414	NOL3 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS18487	Nol3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24969	Nol3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	NOL3	RGD	RGD:708558
Bos taurus	NOL3	VGNC	VGNC:32156
Felis catus	NOL3	VGNC	VGNC:68512
Macaca mulatta	NOL3	VGNC	VGNC:99529
Mus musculus	NOL3	MGD	MGI:1925938
Others	NOL3	NCBI

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