SYT8 - synaptotagmin 8 Gene

中文名称：突触结合蛋白 8

种属: Homo sapiens

关于 SYT8

功能概要

该基因编码突触结合蛋白家族的一个成员。突触结合蛋白是在神经传递和激素分泌中很重要的膜蛋白，这两者都涉及受调节的胞吐作用。已编码蛋白质在人胰岛中的表达与胰岛素基因启动子的活性有关，该启动子位于相距数百千碱基的同一染色体上 (PMID：21336277 和 22928559) 。这种关联会将对葡萄糖醛酸的反应与胰岛素分泌联系起来。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 3 月]

This gene encodes a member of the synaptotagmin protein family. Synaptotagmins are membrane proteins that are important in neurotransmission and hormone secretion, both of which involve regulated exocytosis. Expression of the encoded protein in human pancreatic islets has been connected to activity of the promoter for the Insulin gene, on the same chromosome several hundred kilobases away (PMID: 21336277 and 22928559). This association would link response to gluclose to Insulin secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014]