PKD2L1 - polycystin 2 like 1, transient receptor potential cation channel Gene

中文名称：polycystin 2 like 1，瞬时受体电位阳离子通道

种属: Homo sapiens

同用名: PCL; PKDL; PKD2L; TRPP3

基因 ID: 9033 | 基因类型: protein coding

关于 PKD2L1

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:100,288,149-100,330,228 (from NCBI)

This gene has 4 transcripts (splice variants), 191 orthologues and 10 paralogues. Biased expression in spleen (RPKM 1.0), testis (RPKM 0.9) and 7 other tissues.

功能概要

该基因编码多囊蛋白家族的一个成员。编码的蛋白质包含多个跨膜结构域以及细胞质 N 和 C 末端。该蛋白质可以是参与细胞-细胞/基质相互作用的整合膜蛋白。这种蛋白质起钙调节的非选择性阳离子通道的作用。已发现该基因的两个转录本变体编码不同的亚型。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

PKD2L1 基因产物(2)

mRNA	Protein	Name
NM_001253837.2	NP_001240766.1	polycystic kidney disease 2-like 1 protein isoform 2
NM_016112.3	NP_057196.2	polycystic kidney disease 2-like 1 protein isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables alpha-actinin binding	IPI IPI: 通过物理相互作用推断	17944866	GOA
enables calcium channel activity	IDA IDA: 通过直接分析推断	24336289	GOA
enables calcium ion binding	IDA IDA: 通过直接分析推断	22193359	GOA
enables calcium-activated cation channel activity	IDA IDA: 通过直接分析推断	10517637	GOA
enables calcium-activated potassium channel activity	IDA IDA: 通过直接分析推断	10517637	GOA
enables cytoskeletal protein binding	IPI IPI: 通过物理相互作用推断	12809519	GOA
enables monoatomic cation channel activity	IDA IDA: 通过直接分析推断	17944866	GOA
enables muscle alpha-actinin binding	IPI IPI: 通过物理相互作用推断	17944866	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12525172	GOA
enables sodium channel activity	IDA IDA: 通过直接分析推断	10517637	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in inorganic cation transmembrane transport	IDA IDA: 通过直接分析推断	30004384	GOA
involved in potassium ion transmembrane transport	IDA IDA: 通过直接分析推断	10517637	GOA
involved in protein homotetramerization	IDA IDA: 通过直接分析推断	30004384	GOA
involved in sensory perception of sour taste	IMP IMP: 通过突变表型推断	19812697	GOA
involved in sodium ion transmembrane transport	IDA IDA: 通过直接分析推断	10517637	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of calcium channel complex	IDA IDA: 通过直接分析推断	24336289	GOA
located in intracellular membrane-bounded organelle	IDA IDA: 通过直接分析推断	17944866	GOA
located in membrane	IDA IDA: 通过直接分析推断	19812697	GOA
located in non-motile cilium	IDA IDA: 通过直接分析推断	24336289	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	20538909	GOA
located in plasma membrane	IMP IMP: 通过突变表型推断	17944866	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PKD2L1 蛋白结构

PKD_channel

0
200
400
600
805 a.a.

蛋白主名

其他名称

polycystic kidney disease 2-like 1 protein

polycystin-2 homolog

关联疾病

疾病名称

别名

Kidney Disease

Renal Failure	Kidney Failure
Kidney Diseases	Nephropathy
Abnormality Of The Kidney	Impaired Renal Function Disease
Renal Anomaly	Kidney Dysfunction
Renal Disease	Nephropathies
Renal Failure Adverse Event	Abnormal Renal Function

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 1	PKD1
Adpkd	Polycystic Kidney Disease, Adult, Type I
Apkd1	Potter Type Iii Polycystic Kidney Disease
Polycystic Kidney Disease, Adult	Potter Type Iii Polycystic Kidney Disease, Formerly
Polycystic Kidney Disease, Type 1	Adpkd1
Adult Polycystic Kidney Disease Type 1	Autosomal Dominant Polycystic Kidney Disease 1
Pkd-1	Polycystic Kidney Disease Adult
Polycystic Kidney Disease Type I	Polycystic Kidneys
Polycystic Kidney Disease, Adult Type I	Polycystic Kidney Type 1 Autosomal Dominant Disease
Kidney Disease, Polycystic, Type 1	Polycystic Kidney, Autosomal Dominant
Polycystic Kidney, Type 1 Autosomal Dominant Disease	Polycystic Kidney Diseases

Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2	PKD2
Polycystic Kidney Disease, Adult, Type Ii	Apkd2
Polycystic Kidney Disease, Type 2	Adpkd2
Adult Polycystic Kidney Disease Type 2	Autosomal Dominant Polycystic Kidney Disease 2
Pkd-2	Polycystic Kidney Disease Adult Type Ii
Polycystic Kidney Type 2 Autosomal Dominant Disease	Kidney Disease, Polycystic, Type 2

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10594	PKD2L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PKD2L1	VGNC	VGNC:76008
Rattus norvegicus	PKD2L1	RGD	RGD:1306261
Felis catus	PKD2L1	VGNC	VGNC:68872
Canis familiaris	PKD2L1	VGNC	VGNC:44601
Bos taurus	PKD2L1	VGNC	VGNC:32936
Mus musculus	PKD2L1	MGD	MGI:1352448

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PKD2L1 - polycystin 2 like 1, transient receptor potential cation channel Gene

关于 PKD2L1

功能概要

PKD2L1 基因产物(2)

PKD2L1 蛋白结构

关联疾病

直系同源

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PKD2L1 - polycystin 2 like 1, transient receptor potential cation channel Gene

关于 PKD2L1

功能概要

PKD2L1 基因产物(2)

PKD2L1 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z