2. Gene
  3. RGN - regucalcin Gene

RGN - regucalcin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：调节钙素

种属: Homo sapiens

同用名: RC; GNL; SMP30; HEL-S-41

基因 ID: 9104 | 基因类型: protein coding

关于 RGN

Cytogenetic location: Xp11.3 Genomic coordinates (GRCh38): X:47,078,443-47,093,313 (from NCBI)

This gene has 6 transcripts (splice variants) and 210 orthologues. Biased expression in liver (RPKM 68.0), adrenal (RPKM 65.2) and 11 other tissues.

功能概要

该基因编码的蛋白质是一种高度保守的钙结合蛋白，优先在肝脏和肾脏中表达。它可能在钙稳态中起重要作用。对大鼠的研究表明，这种蛋白质也可能在衰老中发挥作用，因为它显示出与年龄相关的下调。该基因是染色体 Xp11.3-Xp11.23 上基因簇的一部分。可变剪接导致多个转录本变体。[RefSeq 提供，2013 年 9 月]

The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

RGN 基因产物(4)

mRNA Protein Name
NM_001282848.2 NP_001269777.1 regucalcin isoform 2
NM_001282849.2 NP_001269778.1 regucalcin isoform 3
NM_004683.6 NP_004674.1 regucalcin isoform 1
NM_152869.4 NP_690608.1 regucalcin isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
20329768 GOA
enables gluconolactonase activity IDA
IDA: 通过直接分析推断
20329768 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
20329768 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RGN 蛋白结构

SGL

SGL: SMP-30/Gluconolaconase/LRE-like region (16 - 263)

  • 0
  • 100
  • 200
  • 299 a.a.
蛋白主名 其他名称

regucalcin

epididymis secretory protein Li 41

关联疾病

疾病名称 别名
Aging
Hypoascorbemia

Scurvy

Ascorbic Acid Deficiency

Vitamin C Deficiency

Vitamin C, Inability To Synthesize

Deficiency Of Vitamin C

Scorbutus

Vitamin C
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-176537 RGN6024 / 否
HY-RS11896 RGN Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19568 Rgn Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26065 Rgn Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta RGN VGNC VGNC:76912
Canis familiaris RGN VGNC VGNC:45516
Felis catus RGN VGNC VGNC:97604
Mus musculus RGN MGD MGI:108024
Bos taurus RGN VGNC VGNC:33907
Rattus norvegicus RGN RGD RGD:3560
Others RGN NCBI
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