2. Gene
  3. ATP23 - ATP23 metallopeptidase and ATP synthase assembly factor homolog Gene

ATP23 - ATP23 metallopeptidase and ATP synthase assembly factor homolog Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ATP23 金属肽酶和 ATP 合成酶组装因子同系物

种属: Homo sapiens

同用名: KUB3; XRCC6BP1

基因 ID: 91419 | 基因类型: protein coding

关于 ATP23

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:57,941,567-57,959,148 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele and 206 orthologues. Broad expression in testis (RPKM 13.5), bone marrow (RPKM 4.5) and 24 other tissues.

功能概要

由该基因编码的蛋白质在胶质母细胞瘤中被扩增，并与 DNA 依赖性蛋白激酶的 DNA 结合亚基相互作用。该激酶参与双链断裂修复 (DSB) ，编码蛋白的更高表达可提高 DSB 的效率。此外，与同源蛋白质的比较强烈表明该蛋白质是一种在线粒体 ATP 酶生物合成中重要的金属蛋白酶。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2016 年 2 月]

The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

ATP23 基因产物(4)

mRNA Protein Name
NM_001320408.2 NP_001307337.1 mitochondrial inner membrane protease ATP23 homolog isoform b
NM_001320409.2 NP_001307338.1 mitochondrial inner membrane protease ATP23 homolog isoform c
NM_001320410.2 NP_001307339.1 mitochondrial inner membrane protease ATP23 homolog isoform c
NM_033276.4 NP_150592.1 mitochondrial inner membrane protease ATP23 homolog isoform a

ATP23 蛋白结构

Peptidase_M76

Peptidase_M76: Peptidase M76 family (50 - 220)

  • 0
  • 100
  • 200
  • 246 a.a.
蛋白主名 其他名称

mitochondrial inner membrane protease ATP23 homolog

Ku70-binding protein 3

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01190 ATP23 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21489 Atp23 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS28007 Atp23 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ATP23 VGNC VGNC:60019
Bos taurus ATP23 VGNC VGNC:26289
Rattus norvegicus ATP23 RGD RGD:1588587
Canis familiaris ATP23 VGNC VGNC:38252
Mus musculus ATP23 MGD MGI:1916984
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