2. Gene
  3. SLC28A2 - solute carrier family 28 member 2 Gene

SLC28A2 - solute carrier family 28 member 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 28 成员 2

种属: Homo sapiens

同用名: CNT2; HCNT2; SPNT1; HsT17153

基因 ID: 9153 | 基因类型: protein coding

关于 SLC28A2

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,252,234-45,277,846 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues and 2 paralogues. Biased expression in small intestine (RPKM 43.4), duodenum (RPKM 31.3) and 4 other tissues.

功能概要

启用神经递质跨膜转运蛋白活性和核苷跨膜转运蛋白活性。参与多个过程，包括核苷转运；嘌呤碱基跨膜转运；和含嘧啶的化合物跨膜转运。预测位于膜中。预测为刷状缘膜的一部分；涂层囊泡；和囊泡膜。预计是质膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables neurotransmitter transmembrane transporter activity and nucleoside transmembrane transporter activity. Involved in several processes, including nucleoside transport; purine nucleobase transmembrane transport; and pyrimidine-containing compound transmembrane transport. Predicted to be located in membrane. Predicted to be part of brush border membrane; coated vesicle; and vesicle membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC28A2 基因产物(1)

mRNA Protein Name
NM_004212.4 NP_004203.2 sodium/nucleoside cotransporter 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables neurotransmitter transmembrane transporter activity IDA
IDA: 通过直接分析推断
10087507 GOA
enables nucleoside:sodium symporter activity IDA
IDA: 通过直接分析推断
10087507 GOA
enables purine nucleobase transmembrane transporter activity IDA
IDA: 通过直接分析推断
22492015 GOA
enables purine nucleoside transmembrane transporter activity IDA
IDA: 通过直接分析推断
10087507 GOA
enables pyrimidine- and adenosine-specific:sodium symporter activity IDA
IDA: 通过直接分析推断
10087507 GOA
enables uridine transmembrane transporter activity IDA
IDA: 通过直接分析推断
10087507 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenosine transport IDA
IDA: 通过直接分析推断
10087507 GOA
involved in inosine transport IDA
IDA: 通过直接分析推断
10087507 GOA
involved in neurotransmitter transport IDA
IDA: 通过直接分析推断
10087507 GOA
involved in nucleoside transmembrane transport IDA
IDA: 通过直接分析推断
10087507 GOA
involved in purine nucleobase transmembrane transport IDA
IDA: 通过直接分析推断
22492015 GOA
involved in purine nucleoside transmembrane transport IDA
IDA: 通过直接分析推断
10087507 GOA
involved in pyrimidine-containing compound transmembrane transport IDA
IDA: 通过直接分析推断
10087507 GOA
involved in uridine transmembrane transport IDA
IDA: 通过直接分析推断
10087507 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apicolateral plasma membrane IDA
IDA: 通过直接分析推断
35307651 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC28A2 蛋白结构

Nucleos_tra2_N

Nucleos_tra2_N: Na+ dependent nucleoside transporter N-terminus (179 - 251)

Gate

Gate: Nucleoside recognition (259 - 354)

Nucleos_tra2_C

Nucleos_tra2_C: Na+ dependent nucleoside transporter C-terminus (362 - 585)

  • 0
  • 200
  • 400
  • 600
  • 658 a.a.
蛋白主名 其他名称

sodium/nucleoside cotransporter 2

CNT 2

关联疾病

疾病名称 别名
Hyperuricemia

Blood Urate Raized

Uricacidemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13151 SLC28A2 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SLC28A2 VGNC VGNC:77445
Rattus norvegicus SLC28A2 RGD RGD:61840
Bos taurus SLC28A2 VGNC VGNC:34792
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