2. Gene
  3. HTR3B - 5-hydroxytryptamine receptor 3B Gene

HTR3B - 5-hydroxytryptamine receptor 3B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：5-羟色胺受体 3B

种属: Homo sapiens

同用名: 5-HT3B

基因 ID: 9177 | 基因类型: protein coding

关于 HTR3B

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:113,898,923-113,949,079 (from NCBI)

This gene has 3 transcripts (splice variants), 175 orthologues and 45 paralogues. Low expression observed in reference dataset.

功能概要

该基因的产物属于配体门控离子通道受体超家族。该基因编码 5-羟色胺 (5-羟色胺) 3 型受体的 B 亚基，5-羟色胺是一种生物激素，具有神经递质、激素和有丝分裂原的作用。该受体在激活后会在神经元中引起快速的去极化反应。它不像同聚体复合物那样具有功能，但具有亚基 A (HTR3A) 的五异聚体复合物显示出该受体的全部功能特征。[RefSeq 提供，2011 年 8 月]

The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]

HTR3B 基因产物(2)

mRNA Protein Name
NM_001363563.2 NP_001350492.1 5-hydroxytryptamine receptor 3B isoform 2
NM_006028.5 NP_006019.1 5-hydroxytryptamine receptor 3B isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables serotonin-gated monoatomic cation channel activity IDA
IDA: 通过直接分析推断
7565620 GOA
enables serotonin-gated monoatomic cation channel activity IGI
IGI: 通过遗传相互作用推断
9950429 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inorganic cation transmembrane transport IDA
IDA: 通过直接分析推断
17392525 GOA
involved in serotonin receptor signaling pathway IDA
IDA: 通过直接分析推断
17392525 GOA
involved in serotonin-gated cation-selective signaling pathway IDA
IDA: 通过直接分析推断
9950429 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
16571125 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
21138434 GOA
part of serotonin-activated cation-selective channel complex IGI
IGI: 通过遗传相互作用推断
9950429 GOA
part of serotonin-activated cation-selective channel complex IPI
IPI: 通过物理相互作用推断
16116092 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HTR3B 蛋白结构

Neur_chan_LBD

Neur_chan_LBD: Neurotransmitter-gated ion-channel ligand binding domain (34 - 239)

Neur_chan_memb

Neur_chan_memb: Neurotransmitter-gated ion-channel transmembrane region (246 - 331)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 441 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 3B

5-hydroxytryptamine (serotonin) receptor 3B, ionotropic

HTR3B 抗体

目录号 产品名 应用 反应物种
HY-P83873 HTR3B Antibody (YA3570) WB, ICC/IF, FC, ELISA Human

关联疾病

疾病名称 别名
Motion Sickness

Airsickness

Carsickness

Seasickness

Travel Sickness

Riders' Vertigo
Heroin Dependence
Myasthenic Syndrome, Congenital, 15

Congenital Myasthenic Syndrome 15

CMS15

Myasthenic Syndrome, Congenital, Without Tubular Aggregates

Cmswta

Myasthenic Syndrome, Congenital, 15, Without Tubular Aggregates

Congenital Myasthenic Syndrome 15 Without Tubular Aggregates

Myasthenic Syndrome, Congenital, Type 15, Without Tubular Aggregates
Fibromyalgia

Diffuse Myofascial Pain Syndrome

Fibromyalgia Syndrome

Fibromyalgia-Fibromyositis Syndrome

Fibromyositis

Fibrositis

Fms

Myofascial Pain Syndrome

Myofascial Pain Syndromes
Myasthenic Syndrome, Congenital, 9, Associated With Acetylcholine Receptor Deficiency

Congenital Myasthenic Syndrome 9

CMS9

Congenital Myasthenic Syndrome 9, Associated With Acetylcholine Receptor Deficiency

Myasthenic Syndrome, Congenital, Type 9, Associated With Acetylcholine Receptor Deficiency
Pigmented Paravenous Chorioretinal Atrophy

Pigmented Paravenous Retinochoroidal Atrophy

PPCRA

Pprca

Atrophy, Chorioretinal, Pigmented Paravenous
Obsessive-Compulsive Disorder

OCD

Obsessive-Compulsive Disorder, Susceptibility To

Anancastic Neurosis

Obsessive Compulsive Disorder

Anankastic Neurosis

Obsessive-Compulsive Neurosis

Obsessive Compulsive Behavior
Antisocial Personality Disorder

Dissocial Personality Disorder

Asocial Personality

Psychopath.Personality

Psychopathic Personality

Psychopathic Personality Disorder

Sociopathic Personality
Tobacco Addiction

Nicotine Dependence

Tobacco Addiction, Susceptibility To

Nicotine Addiction

Tobacco Use Disorder

Smoking Habit

Nicotine Dependence, Protection Against

Nicotine Addiction, Protection From

Cigarette Habituation

Cigarette Habituation, Susceptibility To

Smoking Habit, Susceptibility To

Nicotine Dependence, Susceptibility To

Nicotine Addiction, Susceptibility To

Addiction, Tobacco, Susceptibility To

Compulsive Tobacco User Syndrome

Tobacco Dependence

Tobacco Dependence Syndrome

Cigarette Addiction

Cigarette Dependence

Smoking Addiction

Smokers Syndrome
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06473 HTR3B Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HTR3B RGD RGD:61820
Felis catus HTR3B VGNC VGNC:67674
Canis familiaris HTR3B VGNC VGNC:41830
Macaca mulatta HTR3B VGNC VGNC:73543
Mus musculus HTR3B MGD MGI:1861899
Bos taurus HTR3B VGNC VGNC:29999
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