2. Gene
  3. FCMR - Fc mu receptor Gene

FCMR - Fc mu receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：Fcμ受体

种属: Homo sapiens

同用名: TOSO; FAIM3; FcmuR

基因 ID: 9214 | 基因类型: protein coding

关于 FCMR

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,903,317-206,921,941 (from NCBI)

This gene has 10 transcripts (splice variants), 92 orthologues and 13 paralogues. Biased expression in lymph node (RPKM 59.4), spleen (RPKM 52.0) and 6 other tissues.

功能概要

Fc 受体特异性结合免疫球蛋白 (Ig) 的 Fc 区，以介导每个 Ig 类别的独特功能。 FAIM3 编码 IgM 的 Fc 受体 (参见 MIM 147020) (Kubagawa 等人，2009 [PubMed 19858324]；Shima 等人，2010 [PubMed 20042454]) 。[OMIM 提供，2010 年 7 月]

Fc Receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

FCMR 基因产物(18)

mRNA Protein Name
NM_001142473.2 NP_001135945.1 fas apoptotic inhibitory molecule 3 isoform b
NM_001193338.2 NP_001180267.1 fas apoptotic inhibitory molecule 3 isoform c precursor
NM_001405862.1 NP_001392791.1 fas apoptotic inhibitory molecule 3 isoform d
NM_001405863.1 NP_001392792.1 fas apoptotic inhibitory molecule 3 isoform d
NM_001405864.1 NP_001392793.1 fas apoptotic inhibitory molecule 3 isoform e precursor
NM_001405865.1 NP_001392794.1 fas apoptotic inhibitory molecule 3 isoform e precursor
NM_001405866.1 NP_001392795.1 fas apoptotic inhibitory molecule 3 isoform f precursor
NM_001405867.1 NP_001392796.1 fas apoptotic inhibitory molecule 3 isoform g precursor
NM_001405868.1 NP_001392797.1 fas apoptotic inhibitory molecule 3 isoform g precursor
NM_001405871.1 NP_001392800.1 fas apoptotic inhibitory molecule 3 isoform a precursor
NM_001405886.1 NP_001392815.1 fas apoptotic inhibitory molecule 3 isoform h
NM_001405887.1 NP_001392816.1 fas apoptotic inhibitory molecule 3 isoform b
NM_001405888.1 NP_001392817.1 fas apoptotic inhibitory molecule 3 isoform j
NM_001405889.1 NP_001392818.1 fas apoptotic inhibitory molecule 3 isoform k precursor
NM_001405890.1 NP_001392819.1 fas apoptotic inhibitory molecule 3 isoform l
NM_001405891.1 NP_001392820.1 fas apoptotic inhibitory molecule 3 isoform m
NM_001405892.1 NP_001392821.1 fas apoptotic inhibitory molecule 3 isoform n precursor
NM_005449.5 NP_005440.1 fas apoptotic inhibitory molecule 3 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables high-affinity IgM receptor activity IDA
IDA: 通过直接分析推断
19858324 GOA
enables polymeric immunoglobulin binding IDA
IDA: 通过直接分析推断
36949194 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
36949194 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Fc receptor-mediated immune complex endocytosis IDA
IDA: 通过直接分析推断
21908732 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early endosome membrane IDA
IDA: 通过直接分析推断
21908732 GOA
located in lysosomal membrane IDA
IDA: 通过直接分析推断
21908732 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
19858324 GOA
located in trans-Golgi network membrane IDA
IDA: 通过直接分析推断
21908732 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FCMR 蛋白结构

ig

ig: Immunoglobulin domain (30 - 105)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
蛋白主名 其他名称

fas apoptotic inhibitory molecule 3

Fc fragment of IgM receptor

关联疾病

疾病名称 别名
Immunodeficiency 54

Natural Killer Cell Deficiency, Familial Isolated

Primary Immunodeficiency With Natural-Killer Cell Deficiency And Adrenal Insufficiency

IMD54

Nkcd

Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect

Nkgcd

Familial Isolated Natural Killer Cell Deficiency

Primary Immunodeficiency Due To Mcm4 Deficiency
Pinguecula
Conjunctival Degeneration
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04838 FCMR Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18931 Fcmr Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25421 Fcmr Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FCMR VGNC VGNC:72507
Rattus norvegicus FCMR RGD RGD:1359282
Canis familiaris FCMR VGNC VGNC:40808
Felis catus FCMR VGNC VGNC:62214
Bos taurus FCMR VGNC VGNC:28938
Mus musculus FCMR MGD MGI:1916419
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