SLC38A5 - solute carrier family 38 member 5 Gene

中文名称：溶质载体家族 38 成员 5

种属: Homo sapiens

同用名: SN2; JM24; SNAT5; pp7194

基因 ID: 92745 | 基因类型: protein coding

关于 SLC38A5

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,458,544-48,470,260 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and 15 paralogues. Broad expression in pancreas (RPKM 19.9), bone marrow (RPKM 15.5) and 18 other tissues.

功能概要

该基因编码的蛋白质是一种系统 N 钠偶联氨基酸转运体。编码的蛋白质将谷氨酰胺、天冬酰胺、组氨酸、丝氨酸、丙氨酸和甘氨酸转运穿过细胞膜，但不转运带电荷的氨基酸、亚氨基酸或 N-烷基化氨基酸。可变剪接导致多个转录变体，但其中一些变体的全长性质尚未确定。[RefSeq 提供，2013 年 8 月]

The protein encoded by this gene is a system N sodium-coupled Amino acid Transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged Amino acids, imino acids, or N-alkylated Amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Aug 2013]

SLC38A5 基因产物(1)

mRNA	Protein	Name
NM_033518.4	NP_277053.2	sodium-coupled neutral amino acid transporter 5

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables L-asparagine transmembrane transporter activity	IMP IMP: 通过突变表型推断	11243884	GOA
enables L-glutamine transmembrane transporter activity	IMP IMP: 通过突变表型推断	11243884	GOA
enables L-histidine transmembrane transporter activity	IMP IMP: 通过突变表型推断	11243884	GOA
enables L-serine transmembrane transporter activity	IMP IMP: 通过突变表型推断	11243884	GOA
enables alanine transmembrane transporter activity	IMP IMP: 通过突变表型推断	11243884	GOA
enables glycine transmembrane transporter activity	IMP IMP: 通过突变表型推断	11243884	GOA
enables neutral amino acid, sodium:proton antiporter activity	IDA IDA: 通过直接分析推断	11243884	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in L-alanine transmembrane transport	IMP IMP: 通过突变表型推断	11243884	GOA
involved in L-histidine transmembrane transport	IMP IMP: 通过突变表型推断	11243884	GOA
involved in asparagine transmembrane transport	IMP IMP: 通过突变表型推断	11243884	GOA
involved in glutamine transport	IMP IMP: 通过突变表型推断	11243884	GOA
involved in glycine transport	IMP IMP: 通过突变表型推断	11243884	GOA
involved in neutral amino acid transport	IDA IDA: 通过直接分析推断	11243884	GOA
involved in serine transport	IMP IMP: 通过突变表型推断	11243884	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC38A5 蛋白结构

Aa_trans

0
100
200
300
400
472 a.a.

蛋白主名

其他名称

sodium-coupled neutral amino acid transporter 5

solute carrier family 38 (amino acid transporter), member 5

关联疾病

疾病名称

别名

Hepatic Encephalopathy

Encephalopathy, Hepatic	Portal-Systemic Encephalopathy
Hepatoencephalopathy	He - [Hepatic Encephalopathy]
Hepatic Encephalopathy Nos	Hepatic Encephalopathy, Stage Unspecified
Hepatic Coma	Hepatocerebral Encephalopathy
Hepatocerebral Intoxication

Mahvash Disease

Gcgr-Related Hyperglucagonemia	MVAH
Alpha-Cell Hyperplasia With Glucagonemia	Nesidioblastosis, Alpha Cell Hyperplasia, Microglucagonoma, And Nonfunctioning Islet Cell Tumor
Nesidioblastosis Alpha Cell Hyperplasia Microglucagonoma And Nonfunctioning Islet Cell Tumor

Brain Edema

Cerebral Edema	Intracranial Swelling
Wet Brain

Osteogenesis Imperfecta, Type Iv

Osteogenesis Imperfecta Type 4	Osteogenesis Imperfecta Type Iv
OI4	Oi, Type Iv
Osteogenesis Imperfecta With Normal Sclerae	Oi Type Iv
Oi Type 4	Osteogenesis Imperfecta With Normal Sclera
Common Variable Oi With Normal Sclerae	Osteogenesis Imperfecta 4
Oi-Iv

Osteogenesis Imperfecta, Type Iii

Osteogenesis Imperfecta Type Iii	OI3
Oi, Type Iii	Osteogenesis Imperfecta Type 3
Oi Type Iii	Oi Type 3
Progressive Deforming Osteogenesis Imperfecta	Severe Osteogenesis Imperfecta
Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae	Progressively Deforming Osteogenesis Imperfecta With Normal Sclera
Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae	Progressively Deforming Oi
Osteogenesis Imperfecta 3	Oi-Iii
Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae

Iminoglycinuria

Iminoglycinuria, Digenic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13223	SLC38A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	SLC38A5	MGD	MGI:2148066
Bos taurus	SLC38A5	VGNC	VGNC:34852
Felis catus	SLC38A5	VGNC	VGNC:65348
Canis familiaris	SLC38A5	VGNC	VGNC:54601
Rattus norvegicus	SLC38A5	RGD	RGD:620702
Macaca mulatta	SLC38A5	VGNC	VGNC:77505

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC38A5 - solute carrier family 38 member 5 Gene

关于 SLC38A5

功能概要

SLC38A5 基因产物(1)

SLC38A5 蛋白结构

关联疾病

直系同源

热门区域

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SLC38A5 - solute carrier family 38 member 5 Gene

关于 SLC38A5

功能概要

SLC38A5 基因产物(1)

SLC38A5 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z