KCNG4 - potassium voltage-gated channel modifier subfamily G member 4 Gene

中文名称：钾电压门控通道调节因子亚科 G 成员 4

种属: Homo sapiens

同用名: KV6.3; KV6.4

基因 ID: 93107 | 基因类型: protein coding

关于 KCNG4

Cytogenetic location: 16q24.1 Genomic coordinates (GRCh38): 16:84,218,657-84,240,012 (from NCBI)

This gene has 2 transcripts (splice variants), 294 orthologues and 31 paralogues. Low expression observed in reference dataset.

功能概要

从功能和结构的角度来看，电压门控钾 (Kv) 通道代表了最复杂的一类电压门控离子通道。它们的不同功能包括调节神经递质释放、心率、胰岛素分泌、神经元兴奋性、上皮电解质转运、平滑肌收缩和细胞体积。该基因编码钾通道、电压门控、G 亚科的成员。该成员作为调节亚基发挥作用。该基因在大脑中有很强的表达。已在正常组织和癌变组织中发现多个选择性剪接变体。[RefSeq 提供，2008 年 7 月]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the Potassium Channel, voltage-gated, subfamily G. This member functions as a modulatory subunit. The gene has strong expression in brain. Multiple alternatively spliced variants have been found in normal and cancerous tissues. [provided by RefSeq, Jul 2008]

KCNG4 基因产物(1)

mRNA	Protein	Name
NM_172347.3	NP_758857.1	potassium voltage-gated channel subfamily G member 4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables potassium channel regulator activity	IDA IDA: 通过直接分析推断	12060745	GOA
enables transmembrane transporter binding	IPI IPI: 通过物理相互作用推断	19074135	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in regulation of potassium ion transmembrane transport	IDA IDA: 通过直接分析推断	19074135	GOA
involved in regulation of potassium ion transport	IDA IDA: 通过直接分析推断	12060745	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	12060745	GOA
part of voltage-gated potassium channel complex	IDA IDA: 通过直接分析推断	19074135	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

KCNG4 蛋白结构

BTB_2

Ion_trans

0
100
200
300
400
519 a.a.

蛋白主名

其他名称

potassium voltage-gated channel subfamily G member 4

potassium channel, voltage gated modifier subfamily G, member 4

关联疾病

疾病名称

别名

Night Blindness, Congenital Stationary, Type 1d

Congenital Stationary Night Blindness 1d	CSNB1D
Csnb, Complete, Autosomal Recessive	Night Blindness, Congenital Stationary , 1d, Autosomal Recessive
Congenital Stationary Night Blindness 1d Autosomal Recessive	Night Blindness, Congenital Stationary, 1d
Complete Autosomal Recessive Csnb	Blindness, Night, Stationary, Congenital, Type 1d

Retinal Cone Dystrophy 3b

RCD3B	Cone Dystrophy With Supernormal Rod Response
Cone Dystrophy With Supernormal Rod Electroretinogram	Cone Dystrophy With Supernormal Rod Responses
Cdsrr	Cone Dystrophy With Night Blindness And Supernormal Rod Responses, Kcnv2-Related
Cone Dystrophy With Night Blindness And Supernormal Rod Responses Kcnv2 Related	Cone Dystrophy With Supernormal Rod Erg
Cone Dystrophy With Supernormal Scotopic Electroretinogram	Cone Dystrophy Retinal 3b
Cone Dystrophy With Night Blindness And Supernormal Rod Responses Kcnv2-Related	Doid:0081022
Dystrophy, Retinal Cone, Type 3b

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS07124	KCNG4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	KCNG4	VGNC	VGNC:42247
Bos taurus	KCNG4	VGNC	VGNC:30444
Macaca mulatta	KCNG4	VGNC	VGNC:82166
Mus musculus	KCNG4	MGD	MGI:1913983
Rattus norvegicus	KCNG4	RGD	RGD:1308553
Felis catus	KCNG4	VGNC	VGNC:63036

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

KCNG4 - potassium voltage-gated channel modifier subfamily G member 4 Gene

关于 KCNG4

功能概要

KCNG4 基因产物(1)

KCNG4 蛋白结构

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

KCNG4 - potassium voltage-gated channel modifier subfamily G member 4 Gene

关于 KCNG4

功能概要

KCNG4 基因产物(1)

KCNG4 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z