NDST3 - N-deacetylase and N-sulfotransferase 3 Gene

中文名称：N-脱乙酰酶和 N-磺基转移酶 3

种属: Homo sapiens

同用名: HSST3

关于 NDST3

功能概要

该基因编码硫酸乙酰肝素/肝素 GlcNAc N-脱乙酰酶/N-磺基转移酶家族的成员。编码的酶是存在于高尔基体中的 II 型跨膜蛋白。这种单体双功能酶催化硫酸乙酰肝素和肝素中 N-乙酰葡糖胺残基的 N-脱乙酰化和 N-硫酸化，这是功能性寡糖序列生物合成所需的初始化学修饰，这些寡糖序列定义了硫酸乙酰肝素和肝素的特异性配体结合活性肝素。[RefSeq 提供，2008 年 11 月]

This gene encodes a member of the heparan sulfate/heparin GlcNAc N-deacetylase/ N-sulfotransferase family. The encoded enzyme is a type II transmembrane protein that resides in the Golgi apparatus. This monomeric bifunctional enzyme catalyzes the N-deacetylation and N-sulfation of N-acetylglucosamine residues in heparan sulfate and heparin, which are the initial chemical modifications required for the biosynthesis of the functional oligosaccharide sequences that define the specific ligand binding activities of heparan sulfate and heparin. [provided by RefSeq, Nov 2008]