2. Gene
  3. ACP4 - acid phosphatase 4 Gene

ACP4 - acid phosphatase 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：酸性磷酸酶 4

种属: Homo sapiens

同用名: ACPT; AI1J

基因 ID: 93650 | 基因类型: protein coding

关于 ACP4

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,790,415-50,795,219 (from NCBI)

This gene has 1 transcript (splice variant), 159 orthologues, 5 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

功能概要

酸性磷酸酶是能够在酸性介质中水解正磷酸酯的酶。该基因在前列腺癌细胞系中被雄激素上调，并被雌激素下调。该基因在睾丸癌组织中的表达水平低于正常组织。该基因编码的蛋白质与前列腺和溶酶体酸性磷酸酶具有结构相似性。已经描述了选择性剪接的转录本变体，但尚未确定它们的生物学有效性。[RefSeq 提供，2008 年 7 月]

Acid phosphatases are Enzymes capable of hydrolyzing orthophosphoric acid esters in an acid medium. This gene is up-regulated by androgens and is down-regulated by estrogens in the prostate Cancer cell line. This gene exhibits a lower level of expression in testicular Cancer tissues than in normal tissues. The protein encoded by this gene has structural similarity to prostatic and lysosomal acid phosphatases. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

ACP4 基因产物(1)

mRNA Protein Name
NM_033068.3 NP_149059.1 testicular acid phosphatase precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
15219672 GOA
enables receptor tyrosine kinase binding IDA
IDA: 通过直接分析推断
15219672 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of ERBB4 signaling pathway IDA
IDA: 通过直接分析推断
15219672 GOA
involved in negative regulation of neuron projection development IDA
IDA: 通过直接分析推断
15219672 GOA
involved in negative regulation of protein processing IMP
IMP: 通过突变表型推断
15219672 GOA
involved in odontogenesis IMP
IMP: 通过突变表型推断
27843125 GOA
involved in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IDA
IDA: 通过直接分析推断
15219672 GOA
involved in regulation of neuronal synaptic plasticity IDA
IDA: 通过直接分析推断
15219672 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACP4 蛋白结构

His_Phos_2

His_Phos_2: Histidine phosphatase superfamily (branch 2) (32 - 337)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
蛋白主名 其他名称

testicular acid phosphatase

acid phosphatase, testicular

关联疾病

疾病名称 别名
Amelogenesis Imperfecta, Type Ij

AI1J

Amelogenesis Imperfecta, Type 1j

Amelogenesis Imperfecta Type 1j

Amelogenesis Imperfecta 1j
Hypoplastic Amelogenesis Imperfecta

Amelogenesis Imperfecta Type 1

Amelogenesis Imperfecta, Hypoplastic Type

Amelogenesis Imperfecta Local Hypoplastic Form
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Congenital Bile Acid Synthesis Defect

3-Beta-Hydroxy-Delta-5-C27-Steroid Oxidoreductase Deficiency

Cba

Cholestasis With Delta(4)-3-Oxosteroid-5-Beta-Reductase Deficiency

Basd

Bile Acid Synthesis Defect, Congenital, 1
Xeroderma Pigmentosum, Complementation Group C

Xeroderma Pigmentosum, Group C

XPC

Xpcc

Xeroderma Pigmentosum Iii

Xp3

Xeroderma Pigmentosum Group C

Xp Group C

Xp, Group C

Xeroderma Pigmentosum, Type 3

Xeroderma Pigmentosum Complementation Group C

XP-C
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00189 ACP4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19306 Acp4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25797 Acp4 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ACP4 VGNC VGNC:52175
Macaca mulatta ACP4 VGNC VGNC:69396
Mus musculus ACP4 MGD MGI:3644563
Felis catus ACP4 VGNC VGNC:59526
Canis familiaris ACP4 VGNC VGNC:53522
Rattus norvegicus ACP4 RGD RGD:1308270
Others ACP4 NCBI
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