2. Gene
  3. Dock2 - dedicator of cyto-kinesis 2 Gene

Dock2 - dedicator of cyto-kinesis 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hch; MBC; CED-5

基因 ID: 94176 | 基因类型: protein coding

关于 Dock2

功能概要

Enables GTPase activator activity. Involved in macropinocytosis; myeloid dendritic cell activation involved in immune response; and positive regulation of phagocytosis. Acts upstream of or within several processes, including T cell activation; immunological synapse formation; and membrane raft polarization. Predicted to be located in cytoplasm; cytoskeleton; and membrane. Is expressed in central nervous system; paraxial mesenchyme; and retina. Human ortholog(s) of this gene implicated in immunodeficiency 40. Orthologous to human DOCK2 (dedicator of cytokinesis 2). [provided by Alliance of Genome Resources, Apr 2022]

Dock2 基因产物(1)

mRNA Protein Name
NM_033374.3 NP_203538.2 dedicator of cytokinesis protein 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IMP
IMP: 通过突变表型推断
12871644 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell activation IMP
IMP: 通过突变表型推断
12871644 MGI
acts upstream of or within T cell proliferation IMP
IMP: 通过突变表型推断
12871644 MGI
acts upstream of or within alpha-beta T cell activation IMP
IMP: 通过突变表型推断
12871644 MGI
acts upstream of or within alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
12871644 MGI
acts upstream of or within chemotaxis IMP
IMP: 通过突变表型推断
11518968 MGI
acts upstream of or within cytoskeleton organization IDA
IDA: 通过直接分析推断
11518968 MGI
acts upstream of or within establishment of T cell polarity IMP
IMP: 通过突变表型推断
12871644 MGI
acts upstream of or within immunological synapse formation IMP
IMP: 通过突变表型推断
12871644 MGI
involved in macropinocytosis IMP
IMP: 通过突变表型推断
21892172 MGI
acts upstream of or within membrane raft polarization IMP
IMP: 通过突变表型推断
12871644 MGI
involved in myeloid dendritic cell activation involved in immune response IMP
IMP: 通过突变表型推断
21892172 MGI
acts upstream of or within negative thymic T cell selection IMP
IMP: 通过突变表型推断
12871644 MGI
involved in positive regulation of phagocytosis IMP
IMP: 通过突变表型推断
21892172 MGI
acts upstream of or within positive thymic T cell selection IMP
IMP: 通过突变表型推断
12871644 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

dedicator of cytokinesis protein 2

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153128 DOCK2-IN-1 Inhibitor 96.20% 否
HY-111355 Cholesterol sulfate Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dock2 NCBI NCBI:1794
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