2. Gene
  3. Smpd3 - sphingomyelin phosphodiesterase 3 Gene

Smpd3 - sphingomyelin phosphodiesterase 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: cca1

基因 ID: 94338 | 基因类型: protein coding

关于 Smpd3

功能概要

Predicted to enable identical protein binding activity; neutral sphingomyelin phosphodiesterase activity; and phospholipid binding activity. Involved in several processes, including positive regulation of NIK/NF-kappaB signaling; positive regulation of cellular biosynthetic process; and positive regulation of exosomal secretion. Located in cytoplasm and membrane. Used to study pulmonary hypertension and transient cerebral ischemia. Biomarker of chronic obstructive pulmonary disease. Orthologous to human SMPD3 (sphingomyelin phosphodiesterase 3). [provided by Alliance of Genome Resources, Apr 2022]

Smpd3 基因产物(1)

mRNA Protein Name
NM_053605.2 NP_446057.2 sphingomyelin phosphodiesterase 3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24007266 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in artery smooth muscle contraction IMP
IMP: 通过突变表型推断
19088082 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
17693623 RGD
involved in dopamine uptake IMP
IMP: 通过突变表型推断
20096352 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
20096352 RGD
involved in positive regulation of ceramide biosynthetic process IMP
IMP: 通过突变表型推断
20096352 RGD
involved in positive regulation of exosomal secretion IMP
IMP: 通过突变表型推断
24743145 RGD
involved in positive regulation of nitric oxide biosynthetic process IMP
IMP: 通过突变表型推断
14720208 RGD
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
14720208 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sphingomyelin phosphodiesterase 3

confluent 3Y1 cell-associated 1

confluent 3Y1 cell-associated protein 1

nSMase-2

nSMase2

neutral sphingomyelin phosphodiesterase 3

neutral sphingomyelinase 2

neutral sphingomyelinase II

sphingomyelin phosphodiesterase 3, neutral membrane

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13449 SMPD3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS21047 Smpd3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS27565 Smpd3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Smpd3 NCBI NCBI:55512
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