2. Gene
  3. AKAP7 - A-kinase anchoring protein 7 Gene

AKAP7 - A-kinase anchoring protein 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：A-激酶锚定蛋白 7

种属: Homo sapiens

同用名: AKAP15; AKAP18

基因 ID: 9465 | 基因类型: protein coding

关于 AKAP7

Cytogenetic location: 6q23.2 Genomic coordinates (GRCh38): 6:131,125,627-131,283,532 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues and 1 paralogue. Broad expression in adrenal (RPKM 12.1), duodenum (RPKM 4.2) and 23 other tissues.

功能概要

该基因编码 A 激酶锚定蛋白 (AKAP) 家族的成员，这是一组功能相关的蛋白质，可与 cAMP 依赖性蛋白激酶 A (PKA) 的调节亚基 (RII) 结合，并将该酶靶向特定的亚细胞区室. AKAP 具有共同的 RII 结合结构域，但包含不同的靶向基序，负责将 PKA 引导至不同的细胞内位置。已经描述了编码不同亚型的三种可变剪接转录本变体。[RefSeq 提供，2011 年 4 月]

This gene encodes a member of the A-kinase anchoring protein (AKAP) family, a group of functionally related proteins that bind to a regulatory subunit (RII) of cAMP-dependent protein kinase A (PKA) and target the enzyme to specific subcellular compartments. AKAPs have a common RII-binding domain, but contain different targeting motifs responsible for directing PKA to distinct intracellular locations. Three alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Apr 2011]

AKAP7 基因产物(9)

mRNA Protein Name
NM_001376570.1 NP_001363499.1 A-kinase anchoring protein 7 isoform 4
NM_001387860.1 NP_001374789.1 A-kinase anchoring protein 7 isoform 5
NM_001387861.1 NP_001374790.1 A-kinase anchoring protein 7 isoform 6
NM_001387862.1 NP_001374791.1 A-kinase anchoring protein 7 isoform 7
NM_001387863.1 NP_001374792.1 A-kinase anchoring protein 7 isoform 8
NM_001387864.1 NP_001374793.1 A-kinase anchoring protein 7 isoform 9
NM_004842.4 NP_004833.1 A-kinase anchoring protein 7 isoform alpha
NM_016377.4 NP_057461.2 A-kinase anchoring protein 7 isoform gamma
NM_138633.3 NP_619539.1 A-kinase anchoring protein 7 isoform beta
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17244820 GOA
enables protein kinase A binding IDA
IDA: 通过直接分析推断
9545239 GOA
enables protein kinase A binding IPI
IPI: 通过物理相互作用推断
25097019 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to cAMP IDA
IDA: 通过直接分析推断
11299204 GOA
involved in positive regulation of delayed rectifier potassium channel activity IDA
IDA: 通过直接分析推断
11299204 GOA
involved in positive regulation of potassium ion transmembrane transport IDA
IDA: 通过直接分析推断
11299204 GOA
involved in regulation of membrane repolarization IDA
IDA: 通过直接分析推断
11299204 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
10613906 GOA
located in cytosol IDA
IDA: 通过直接分析推断
10613906 GOA
located in lateral plasma membrane IDA
IDA: 通过直接分析推断
10613906 GOA
part of protein-containing complex IDA
IDA: 通过直接分析推断
25097019 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AKAP7 蛋白结构

AKAP7_NLS

AKAP7_NLS: AKAP7 2'5' RNA ligase-like domain (85 - 281)

AKAP7_RIRII_bdg

AKAP7_RIRII_bdg: PKA-RI-RII subunit binding domain of A-kinase anchor protein (289 - 348)

  • 0
  • 100
  • 200
  • 300
  • 348 a.a.
蛋白主名 其他名称

A-kinase anchoring protein 7

A kinase (PRKA) anchor protein 7

关联疾病

疾病名称 别名
Familial Febrile Seizures

Familial Febrile Convulsions

Feb

Febrile Seizures, Familial
Long Qt Syndrome 1

Romano-Ward Syndrome

LQT1

Ward-Romano Syndrome

Rws

Ventricular Fibrillation With Prolonged Qt Interval

Wrs

Long Qt Syndrome 1, Acquired, Susceptibility To

Long Qt Syndrome 1, Acquired

Romano-Ward Long Qt Syndrome

Long Qt Syndrome Type 1

Long Qt Syndrome-1

Acquired Susceptibility To Long Qt Syndrome 1

Qt Syndrome, Long, Type 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00522 AKAP7 Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus AKAP7 RGD RGD:1303071
Canis familiaris AKAP7 VGNC VGNC:37760
Bos taurus AKAP7 VGNC VGNC:25788
Macaca mulatta AKAP7 VGNC VGNC:69772
Mus musculus AKAP7 MGD MGI:1859150
Felis catus AKAP7 VGNC VGNC:59717
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