SLC4A7 - solute carrier family 4 member 7 Gene

中文名称：溶质载体家族 4 成员 7

种属: Homo sapiens

同用名: NBC2; NBC3; SBC2; NBCN1; SLC4A6

基因 ID: 9497 | 基因类型: protein coding

关于 SLC4A7

Cytogenetic location: 3p24.1 Genomic coordinates (GRCh38): 3:27,372,723-27,484,384 (from NCBI)

This gene has 18 transcripts (splice variants), 276 orthologues and 9 paralogues. Ubiquitous expression in duodenum (RPKM 27.5), small intestine (RPKM 8.8) and 20 other tissues.

功能概要

该基因座编码碳酸氢钠协同转运蛋白。编码的跨膜蛋白似乎以 1:1 的比例转运钠离子和碳酸氢根离子，因此被认为是电中性协同转运蛋白。编码的蛋白质可能在调节涉及视觉和听觉感觉传递的细胞内 pH 中起关键作用。已经描述了编码不同同种型的选择性剪接转录物变体。[RefSeq 提供，2012 年 4 月]

This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]

SLC4A7 基因产物(9)

mRNA	Protein	Name
NM_001258379.2	NP_001245308.1	sodium bicarbonate cotransporter 3 isoform b
NM_001258380.2	NP_001245309.1	sodium bicarbonate cotransporter 3 isoform c
NM_001321103.2	NP_001308032.1	sodium bicarbonate cotransporter 3 isoform d
NM_001321104.2	NP_001308033.1	sodium bicarbonate cotransporter 3 isoform e
NM_001321105.2	NP_001308034.1	sodium bicarbonate cotransporter 3 isoform f
NM_001321106.2	NP_001308035.1	sodium bicarbonate cotransporter 3 isoform g
NM_001321107.2	NP_001308036.1	sodium bicarbonate cotransporter 3 isoform h
NM_001321108.2	NP_001308037.1	sodium bicarbonate cotransporter 3 isoform i
NM_003615.5	NP_003606.3	sodium bicarbonate cotransporter 3 isoform a

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	14736710	GOA
enables sodium:bicarbonate symporter activity	IDA IDA: 通过直接分析推断	10347222	GOA
enables sodium:bicarbonate symporter activity	IMP IMP: 通过突变表型推断	14578046	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to growth factor stimulus	IDA IDA: 通过直接分析推断	35772404	GOA
involved in phagosome acidification	IDA IDA: 通过直接分析推断	29779931	GOA
involved in purine nucleotide biosynthetic process	IMP IMP: 通过突变表型推断	35772404	GOA
involved in pyrimidine nucleotide biosynthetic process	IMP IMP: 通过突变表型推断	35772404	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	17715183	GOA
located in membrane	IDA IDA: 通过直接分析推断	27717805	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	29779931	GOA
located in plasma membrane	IMP IMP: 通过突变表型推断	14578046	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC4A7 蛋白结构

Band_3_cyto

HCO3_cotransp

0
200
400
600
800
1000
1214 a.a.

蛋白主名

其他名称

sodium bicarbonate cotransporter 3

bicarbonate transporter

关联疾病

疾病名称

别名

Corneal Dystrophy, Band-Shaped

Band Keratopathy

Band-Shaped Keratopathy

Complex Partial Epilepsy

Epilepsy, Complex Partial	Complex Partial Epileptic Seizure
Epilepsy, Psychomotor	Psychomotor Epilepsy

Intestinal Impaction

Corneal Dystrophy And Perceptive Deafness

Corneal Dystrophy-Perceptive Deafness Syndrome	CDPD
Harboyan Syndrome	Cdpd1
Corneal Dystrophy And Sensorineural Deafness	Corneal Endothelial Dystrophy And Perceptive Deafness
Corneal Dystrophy With Progressive Deafness	Congenital Corneal Dystrophy, Progressive Sensorineural Deafness
Corneal Dystrophy With Progressive Hearing Loss	Corneal Dystrophy-Perceptive Hearing Loss Syndrome
Dystrophy, Corneal, Endothelial, And Perceptive Deafness

Usher Syndrome

Deafness-Retinitis Pigmentosa Syndrome	Dystrophia Retinae Pigmentosa-Dysostosis Syndrome
Graefe-Usher Syndrome	Hallgren Syndrome
Usher'S Syndrome	Retinitis Pigmentosa-Deafness Syndrome
Retinitis Pigmentosa-Hearing Loss Syndrome	Ush
Usher Syndromes

Renal Tubular Acidosis

Acidosis Renal Tubular	Acidosis, Renal Tubular
Lightwood-Albright Syndrome	Lightwood Syndrome
Idiopathic Infantile Hypercalcemia - Mild Form	Kidney Tubular Acidosis
Renal Tubule Acidosis	Kidney Acidosis
Renal Acidosis	Renal Hyperchloremic Acidosis
Rta - [Renal Tubular Acidosis]

Corneal Degeneration

Degenerative Corneal Opacity

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13272	SLC4A7 Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS21936	Slc4a7 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	SLC4A7	VGNC	VGNC:77606
Canis familiaris	SLC4A7	VGNC	VGNC:46436
Bos taurus	SLC4A7	VGNC	VGNC:34896
Rattus norvegicus	SLC4A7	RGD	RGD:621208
Felis catus	SLC4A7	VGNC	VGNC:65391
Mus musculus	SLC4A7	MGD	MGI:2443878

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC4A7 - solute carrier family 4 member 7 Gene

关于 SLC4A7

功能概要

SLC4A7 基因产物(9)

SLC4A7 蛋白结构

关联疾病

直系同源

热门区域

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SLC4A7 - solute carrier family 4 member 7 Gene

关于 SLC4A7

功能概要

SLC4A7 基因产物(9)

SLC4A7 蛋白结构

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z