TP53I3 - tumor protein p53 inducible protein 3 Gene

中文名称：肿瘤蛋白 p53 诱导蛋白 3

种属: Homo sapiens

同用名: PIG3

关于 TP53I3

功能概要

由该基因编码的蛋白质类似于氧化还原酶，它们是参与细胞对氧化应激和辐射的反应的酶。该基因由肿瘤抑制基因 p53 诱导，被认为与 p53 介导的细胞死亡有关。它在其启动子区域和下游五核苷酸微卫星序列中包含一个 p53 共有结合位点。已显示 P53 通过与下游五核苷酸微卫星序列相互作用来转录激活该基因。微卫星是多态性的，具有不同数量的五核苷酸重复，与 p53 的转录激活程度直接相关。有人提出微卫星多态性可能与对癌症的不同易感性有关。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 5 月]

The protein encoded by this gene is similar to oxidoreductases, which are Enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to Cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]