ATP5MF - ATP synthase membrane subunit f Gene

中文名称：ATP 合酶膜亚基 f

种属: Homo sapiens

同用名: ATP5J2; ATP5JL

关于 ATP5MF

功能概要

线粒体 ATP 合酶催化 ATP 合成，利用氧化磷酸化过程中跨内膜的质子电化学梯度。它由两个连接的多亚基复合物组成：可溶性催化核心 F1 和跨膜成分 Fo，后者包含质子通道。线粒体 ATP 合酶的催化部分由五个不同的亚基 (α、β、γ、δ 和 epsilon) 组成，这些亚基的化学计量为 3 个 alpha、3 个 beta 以及 gamma、delta 和 epsilon 亚基的单个代表。质子通道可能有九个亚基 (a、b、c、d、e、f、g、F6 和 8) 。该基因编码 Fo 复合体的 f 亚基。已经为该基因鉴定了编码不同亚型的可变剪接转录物变体。这个基因有多个假基因。该基因与下游五肽重复结构域 1 (PTCD1) 基因之间也存在自然发生的通读转录。[RefSeq 提供，2010 年 11 月]

Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The catalytic portion of mitochondrial ATP Synthase consists of five different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the f subunit of the Fo complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. This gene has multiple pseudogenes. Naturally occurring read-through transcription also exists between this gene and the downstream pentatricopeptide repeat domain 1 (PTCD1) gene. [provided by RefSeq, Nov 2010]