2. Gene
  3. Prg4 - proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) Gene

Prg4 - proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: MSF; SZP; CACP; JCAP; DOL54; lubricin

基因 ID: 96875 | 基因类型: protein coding

关于 Prg4

功能概要

Predicted to enable polysaccharide binding activity and scavenger receptor activity. Acts upstream of or within hematopoietic stem cell proliferation; negative regulation of interleukin-6 production; and regulation of cell population proliferation. Located in extracellular space. Is expressed in brain; larynx; musculoskeletal system; and spinal component of peripheral nervous system. Human ortholog(s) of this gene implicated in camptodactyly-arthropathy-coxa vara-pericarditis syndrome and pericarditis. Orthologous to human PRG4 (proteoglycan 4). [provided by Alliance of Genome Resources, Apr 2022]

Prg4 基因产物(2)

mRNA Protein Name
NM_001110146.1 NP_001103616.1 proteoglycan 4 isoform 2 precursor
NM_021400.3 NP_067375.3 proteoglycan 4 isoform 1 precursor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within hematopoietic stem cell proliferation IMP
IMP: 通过突变表型推断
21939632 MGI
acts upstream of interleukin-6 production IMP
IMP: 通过突变表型推断
21939632 MGI
acts upstream of or within negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
21939632 MGI
acts upstream of or within regulation of cell population proliferation IMP
IMP: 通过突变表型推断
15719068 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
15719068 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

proteoglycan 4

megakaryocyte-stimulating factor

proteoglycan 3

superficial zone proteoglycan

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11090 PRG4 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19634 Prg4 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26129 Prg4 Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P99690 Ledelabricin alfa / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Prg4 NCBI NCBI:10216
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