ESPL1 - extra spindle pole bodies like 1, separase Gene

中文名称：额外的纺锤体样 1，分离酶

种属: Homo sapiens

同用名: ESP1; SEPA

关于 ESPL1

功能概要

姐妹染色单体在后期之前的稳定凝聚以及它们在后期的及时分离对于染色体遗传至关重要。在脊椎动物中，姐妹染色单体的凝聚通过不同的机制分两步释放。第一步涉及 cohesin 复合物中 STAG1 (MIM 604358) 或 STAG2 (MIM 300826) 的磷酸化。第二步涉及 ESPL1 或分离酶对粘连蛋白亚基 SCC1 (RAD21；MIM 606462) 的切割，这会启动姐妹染色单体的最终分离 (Sun 等人，2009 [PubMed 19345191]) 。[OMIM 提供，2010 年 11 月] ]

Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21; MIM 606462) by ESPL1, or Separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010]