2. Gene
  3. ST18 - ST18 C2H2C-type zinc finger transcription factor Gene

ST18 - ST18 C2H2C-type zinc finger transcription factor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：ST18 C2H2C 型锌指转录因子

种属: Homo sapiens

同用名: NZF3; NZF-3; ZNF387; ZC2H2C3; ZC2HC10

基因 ID: 9705 | 基因类型: protein coding

关于 ST18

Cytogenetic location: 8q11.23 Genomic coordinates (GRCh38): 8:52,110,838-52,409,879 (from NCBI)

This gene has 27 transcripts (splice variants), 215 orthologues and 5 paralogues. Biased expression in brain (RPKM 3.7), stomach (RPKM 0.7) and 3 other tissues.

功能概要

启用 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。参与细胞因子介导的信号通路；细胞群增殖的负调节；氮化合物代谢过程的正向调控。位于核内。蛋白质-DNA 复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cytokine-mediated signaling pathway; negative regulation of cell population proliferation; and positive regulation of nitrogen compound metabolic process. Located in nucleus. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2022]

ST18 基因产物(60)

mRNA Protein Name
NM_001352826.2 NP_001339755.1 suppression of tumorigenicity 18 protein isoform a
NM_001352827.2 NP_001339756.1 suppression of tumorigenicity 18 protein isoform a
NM_001352828.2 NP_001339757.1 suppression of tumorigenicity 18 protein isoform a
NM_001352829.2 NP_001339758.1 suppression of tumorigenicity 18 protein isoform a
NM_001352830.2 NP_001339759.1 suppression of tumorigenicity 18 protein isoform a
NM_001352831.2 NP_001339760.1 suppression of tumorigenicity 18 protein isoform a
NM_001352832.2 NP_001339761.1 suppression of tumorigenicity 18 protein isoform a
NM_001352833.2 NP_001339762.1 suppression of tumorigenicity 18 protein isoform a
NM_001352834.2 NP_001339763.1 suppression of tumorigenicity 18 protein isoform a
NM_001352835.2 NP_001339764.1 suppression of tumorigenicity 18 protein isoform a
NM_001352836.2 NP_001339765.1 suppression of tumorigenicity 18 protein isoform a
NM_001352837.2 NP_001339766.1 suppression of tumorigenicity 18 protein isoform a
NM_001352838.2 NP_001339767.1 suppression of tumorigenicity 18 protein isoform a
NM_001352839.2 NP_001339768.1 suppression of tumorigenicity 18 protein isoform a
NM_001352840.2 NP_001339769.1 suppression of tumorigenicity 18 protein isoform a
NM_001352841.2 NP_001339770.1 suppression of tumorigenicity 18 protein isoform a
NM_001352842.2 NP_001339771.1 suppression of tumorigenicity 18 protein isoform a
NM_001352843.2 NP_001339772.1 suppression of tumorigenicity 18 protein isoform a
NM_001352844.2 NP_001339773.1 suppression of tumorigenicity 18 protein isoform a
NM_001352845.2 NP_001339774.1 suppression of tumorigenicity 18 protein isoform a
NM_001352846.2 NP_001339775.1 suppression of tumorigenicity 18 protein isoform a
NM_001352847.2 NP_001339776.1 suppression of tumorigenicity 18 protein isoform a
NM_001352848.2 NP_001339777.1 suppression of tumorigenicity 18 protein isoform a
NM_001352849.2 NP_001339778.1 suppression of tumorigenicity 18 protein isoform a
NM_001352850.2 NP_001339779.1 suppression of tumorigenicity 18 protein isoform a
NM_001352851.2 NP_001339780.1 suppression of tumorigenicity 18 protein isoform a
NM_001352852.2 NP_001339781.1 suppression of tumorigenicity 18 protein isoform a
NM_001352853.2 NP_001339782.1 suppression of tumorigenicity 18 protein isoform a
NM_001352854.2 NP_001339783.1 suppression of tumorigenicity 18 protein isoform a
NM_001352855.2 NP_001339784.1 suppression of tumorigenicity 18 protein isoform a
NM_001352856.2 NP_001339785.1 suppression of tumorigenicity 18 protein isoform a
NM_001352857.2 NP_001339786.1 suppression of tumorigenicity 18 protein isoform a
NM_001352858.2 NP_001339787.1 suppression of tumorigenicity 18 protein isoform c
NM_001352859.2 NP_001339788.1 suppression of tumorigenicity 18 protein isoform c
NM_001352860.2 NP_001339789.1 suppression of tumorigenicity 18 protein isoform c
NM_001352861.2 NP_001339790.1 suppression of tumorigenicity 18 protein isoform b
NM_001352862.2 NP_001339791.1 suppression of tumorigenicity 18 protein isoform b
NM_001352863.2 NP_001339792.1 suppression of tumorigenicity 18 protein isoform b
NM_001352864.2 NP_001339793.1 suppression of tumorigenicity 18 protein isoform b
NM_001352865.2 NP_001339794.1 suppression of tumorigenicity 18 protein isoform b
NM_001352866.2 NP_001339795.1 suppression of tumorigenicity 18 protein isoform b
NM_001352867.2 NP_001339796.1 suppression of tumorigenicity 18 protein isoform b
NM_001352868.2 NP_001339797.1 suppression of tumorigenicity 18 protein isoform b
NM_001352869.2 NP_001339798.1 suppression of tumorigenicity 18 protein isoform b
NM_001352870.2 NP_001339799.1 suppression of tumorigenicity 18 protein isoform d
NM_001352871.2 NP_001339800.1 suppression of tumorigenicity 18 protein isoform d
NM_001352872.2 NP_001339801.1 suppression of tumorigenicity 18 protein isoform d
NM_001352873.2 NP_001339802.1 suppression of tumorigenicity 18 protein isoform d
NM_001352874.2 NP_001339803.1 suppression of tumorigenicity 18 protein isoform d
NM_001352875.2 NP_001339804.1 suppression of tumorigenicity 18 protein isoform d
NM_001352876.2 NP_001339805.1 suppression of tumorigenicity 18 protein isoform f
NM_001352877.2 NP_001339806.1 suppression of tumorigenicity 18 protein isoform e
NM_001352878.2 NP_001339807.1 suppression of tumorigenicity 18 protein isoform e
NM_001352879.1 NP_001339808.1 suppression of tumorigenicity 18 protein isoform g
NM_001352880.1 NP_001339809.1 suppression of tumorigenicity 18 protein isoform g
NM_001352881.1 NP_001339810.1 suppression of tumorigenicity 18 protein isoform g
NM_001352882.1 NP_001339811.1 suppression of tumorigenicity 18 protein isoform g
NM_001352883.2 NP_001339812.1 suppression of tumorigenicity 18 protein isoform h
NM_001352884.2 NP_001339813.1 suppression of tumorigenicity 18 protein isoform h
NM_014682.3 NP_055497.1 suppression of tumorigenicity 18 protein isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
18676404 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in interleukin-1-mediated signaling pathway IMP
IMP: 通过突变表型推断
18676404 GOA
involved in interleukin-6-mediated signaling pathway IMP
IMP: 通过突变表型推断
18676404 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
15489893 GOA
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
IMP: 通过突变表型推断
18676404 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
18676404 GOA
involved in tumor necrosis factor-mediated signaling pathway IMP
IMP: 通过突变表型推断
18676404 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
15489893 GOA
part of protein-DNA complex IDA
IDA: 通过直接分析推断
18676404 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ST18 蛋白结构

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (366 - 394)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (410 - 439)

MYT1

MYT1: Myelin transcription factor 1 (480 - 716)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (723 - 751)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (765 - 795)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (813 - 843)

zf-C2HC

zf-C2HC: Zinc finger, C2HC type (868 - 895)

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  • 1047 a.a.
蛋白主名 其他名称

suppression of tumorigenicity 18 protein

ST18, C2H2C-type zinc finger

关联疾病

疾病名称 别名
Pemphigus
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13845 ST18 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19643 St18 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS26136 St18 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus ST18 RGD RGD:708566
Felis catus ST18 VGNC VGNC:65718
Canis familiaris ST18 VGNC VGNC:46849
Bos taurus ST18 VGNC VGNC:35330
Macaca mulatta ST18 VGNC VGNC:77959
Mus musculus ST18 MGD MGI:2446700
Others ST18 NCBI
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