1. Gene
  2. HELZ - helicase with zinc finger Gene

HELZ - helicase with zinc finger Gene

中文名称:锌指解旋酶

种属: Homo sapiens

同用名: DHRC; DRHC; HUMORF5

基因 ID: 9931 | 基因类型: protein coding

关于 HELZ

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:67,070,444-67,245,989 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and 10 paralogues. Ubiquitous expression in testis (RPKM 6.5), ovary (RPKM 6.3) and 25 other tissues.

功能概要

HELZ 是 I 类 RNA 解旋酶超家族的成员。 RNA 解旋酶通过展开双链区域来改变 RNA 的构象,从而改变 RNA 分子的生物活性并调节与其他蛋白质的接触 (Wagner 等人,1999 [PubMed 10471385]) 。[OMIM 提供,2008 年 3 月]

HELZ is a member of the superfamily I class of RNA helicases. RNA helicases alter the conformation of RNA by unwinding double-stranded regions, thereby altering the biologic activity of the RNA molecule and regulating access to Other proteins (Wagner et al., 1999 [PubMed 10471385]).[supplied by OMIM, Mar 2008]

HELZ 基因产物(2)

mRNA Protein Name
NM_001330447.2 NP_001317376.2 probable helicase with zinc finger domain isoform 2
NM_014877.4 NP_055692.3 probable helicase with zinc finger domain isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
24606901 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

HELZ 蛋白结构

zf-CCCH

zf-CCCH: Zinc finger C-x8-C-x5-C-x3-H type (and similar) (181 - 205)

AAA_11

AAA_11: AAA domain (642 - 754)

AAA_11

AAA_11: AAA domain (758 - 833)

AAA_12

AAA_12: AAA domain (841 - 1050)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1800
  • 1942 a.a.
蛋白主名 其他名称

probable helicase with zinc finger domain

down-regulated in human cancers protein

直系同源

种属 基因名 来源 基因 ID
Felis catus HELZ VGNC VGNC:62792
Macaca mulatta HELZ VGNC VGNC:73178
Rattus norvegicus HELZ RGD RGD:1307049
Canis familiaris HELZ VGNC VGNC:41652
Mus musculus HELZ MGD MGI:1925705
Bos taurus HELZ VGNC VGNC:57142