MED13 - mediator complex subunit 13 Gene

中文名称：调解复合体亚基 13

种属: Homo sapiens

同用名: MRD61; ARC250; THRAP1; DRIP250; HSPC221; TRAP240

基因 ID: 9969 | 基因类型: protein coding

关于 MED13

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:61,942,605-62,065,278 (from NCBI)

This gene has 6 transcripts (splice variants), 283 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 10.6), testis (RPKM 10.3) and 25 other tissues.

功能概要

该基因编码介体复合体 (也称为 TRAP、SMCC、DRIP 或 ARC) 的一个组分，这是一种转录共激活因子复合体，被认为是几乎所有基因表达所必需的。介体复合物由转录激活因子或核受体募集以诱导基因表达，可能通过与 RNA 聚合酶 II 相互作用并促进转录前起始复合物的形成。该基因的产物被提议与 MED12、细胞周期蛋白 C 和 CDK8 形成一个子复合体，可以负调节介体的反式激活。[RefSeq 提供，2008 年 7 月]

This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. The product of this gene is proposed to form a sub-complex with MED12, cyclin C, and CDK8 that can negatively regulate transactivation by mediator. [provided by RefSeq, Jul 2008]

MED13 基因产物(1)

mRNA	Protein	Name
NM_005121.3	NP_005112.2	mediator of RNA polymerase II transcription subunit 13

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables nuclear thyroid hormone receptor binding	IDA IDA: 通过直接分析推断	10198638	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12421765	GOA
enables transcription coactivator activity	IDA IDA: 通过直接分析推断	12218053	GOA
enables transcription coregulator activity	IDA IDA: 通过直接分析推断	10198638	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	10198638	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: 通过直接分析推断	12218053	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of CKM complex	IPI IPI: 通过物理相互作用推断	19047373	GOA
part of mediator complex	IDA IDA: 通过直接分析推断	10198638	GOA
located in nucleus	IDA IDA: 通过直接分析推断	10235267	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MED13 蛋白结构

Med13_N

Med13_C

0
400
800
1200
1600
2000
2174 a.a.

蛋白主名

其他名称

mediator of RNA polymerase II transcription subunit 13

activator-recruited cofactor 250 kDa component

关联疾病

疾病名称

别名

Intellectual Developmental Disorder, Autosomal Dominant 61

MRD61

Mental Retardation, Autosomal Dominant 61

Non-Specific Syndromic Intellectual Disability

Complex Neurodevelopmental Disorder

Opitz-Kaveggia Syndrome

Fg Syndrome	Fgs1
Fgs	Keller Syndrome
OKS	Fg Syndrome 1
Fg Syndrome Type 1	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum
Intellectual Disability, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum	Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum

Ohdo Syndrome

Young Simpson Syndrome	Ohdo Blepharophimosis Syndrome
Blepharophimosis Syndrome Ohdo Type	Blepharophimosis Intellectual Disability Syndromes
Bmrs	Blepharophimosis-Intellectual Disability Syndrome
Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth	Sbbys Syndrome
Say Barber Biesecker Young-Simpson Syndrome	Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type
Bmrs, Ohdo Type	Blepharophimosis Syndrome, Ohdo Type
Ohdo-Madokoro-Sonoda Syndrome	Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type
Blepharophimosis - Intellectual Disability Syndrome

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS08283	MED13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS08284	MED13L Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	MED13	VGNC	VGNC:31350
Canis familiaris	MED13	VGNC	VGNC:43122
Rattus norvegicus	MED13	RGD	RGD:1304829
Macaca mulatta	MED13	VGNC	VGNC:74554
Mus musculus	MED13	MGD	MGI:3029632
Felis catus	MED13	VGNC	VGNC:63433

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MED13 - mediator complex subunit 13 Gene

关于 MED13

功能概要

MED13 基因产物(1)

MED13 蛋白结构

关联疾病

直系同源

热门区域

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MED13 - mediator complex subunit 13 Gene

关于 MED13

功能概要

MED13 基因产物(1)

MED13 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

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Q

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T

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