2. Academic Validation
  3. Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues

Modeling directed design and biological evaluation of quinazolinones as non-peptidic growth hormone secretagogues

  • Bioorg Med Chem Lett. 2000 Jan 3;10(1):5-8. doi: 10.1016/s0960-894x(99)00584-3.
Z Ye 1,  Y Gao,  R K Bakshi,  M H Chen,  S P Rohrer,  S D Feighner,  S S Pong,  A D Howard,  A Blake,  E T Birzin,  L Locco,  R M Parmar,  W W Chan,  J M Schaeffer,  R G Smith,  A A Patchett,  R P Nargund
Affiliations

Affiliation

  • 1 Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA.
PMID: 10636230 DOI: 10.1016/s0960-894x(99)00584-3
Abstract

Quinazolinone derivatives were synthesized and evaluated as non-peptidic growth hormone secretagogues. Modeling guided design of quinazolinone compound 21 led to a potency enhancement of greater than 200-fold compared to human growth hormone secretagogue affinity of a screening lead 4.

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