2. Academic Validation
  3. A novel cytotoxic C-methylated biflavone from the stem of Cephalotaxus wilsoniana

A novel cytotoxic C-methylated biflavone from the stem of Cephalotaxus wilsoniana

  • Chem Pharm Bull (Tokyo). 2000 Mar;48(3):440-1. doi: 10.1248/cpb.48.440.
Y H Kuo 1,  C H Lin,  S Y Hwang,  Y C Shen,  Y L Lee,  L Shyh-Yuan
Affiliations

Affiliation

  • 1 National Research Institute of Chinese Medicine, and Chinese Culture University, Taipei, Taiwan, ROC.
PMID: 10726874 DOI: 10.1248/cpb.48.440
Abstract

Bioassay-directed fractionation of an ethanolic extract of Cephalotaxus wilsoniana has resulted in the isolation of a novel C-methylated biflavone, taiwanhomoflavone-A (1). Its structure was elucidated on the basis of spectroscopic analysis. Taiwanhomoflavone-A is cytotoxic with ED50 values of 3.4, 1.0, 2.0 and 2.5 microg/ml, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, Hepa-3B hepatoma, and Hela cervix tumor cells.

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