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  3. Trichomonas vaginalis: microtubule cytoskeleton distribution using fluorescent taxoid

Trichomonas vaginalis: microtubule cytoskeleton distribution using fluorescent taxoid

  • Exp Parasitol. 2002 Oct;102(2):113-6. doi: 10.1016/s0014-4894(03)00030-4.
Sheila B Lecke 1,  Tiana Tasca,  André A Souto,  Geraldo A De Carli
Affiliations

Affiliation

  • 1 Laboratório de Parasitologia Clínica, Faculdade de Farmácia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.
PMID: 12706747 DOI: 10.1016/s0014-4894(03)00030-4
Abstract

Trichomonas vaginalis is a flagellated parasitic protist of the human urogenital tract. The Parasite has a poorly known Cytoskeleton formed by an axostyle and a pelta, which are formed by stable structures such as microtubules, essential for the maintenance of cell shape and organization. FLUTAX-2 is an active fluorescent derivative of Taxol, binds to alphabeta-tubulin dimer polymerized. In this paper we present the analysis of microtubule distribution in living trophozoites of T. vaginalis using FLUTAX-2.

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