2. Academic Validation
  3. Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells

Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells

  • J Nat Prod. 2005 Jun;68(6):947-50. doi: 10.1021/np050029m.
Yu-Dong Zhou 1,  Yong-Pil Kim,  Kaleem Asjad Mohammed,  Deborah K Jones,  Ilias Muhammad,  D Chuck Dunbar,  Dale G Nagle
Affiliations

Affiliation

  • 1 National Center for Natural Products Research and Department of Pharmacognosy, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, 38677, USA.
PMID: 15974627 DOI: 10.1021/np050029m
Abstract

Klugine (1), isocephaeline (2), and emetine (4) inhibited hypoxia-inducible factor-1 (HIF-1) activation by hypoxia in T47D breast tumor cells (IC(50) values 0.2, 1.1, and 0.11 muM, respectively). Compounds 1, 2, and 4 inhibited both hypoxia- and iron chelator-induced HIF-1 activation by blocking HIF-1alpha protein accumulation.

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