2. Academic Validation
  3. Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis

Novel CCR1 antagonists with oral activity in the mouse collagen induced arthritis

  • Bioorg Med Chem Lett. 2005 Dec 1;15(23):5160-4. doi: 10.1016/j.bmcl.2005.08.057.
Laszlo Revesz 1,  Birgit Bollbuck,  Thomas Buhl,  Joerg Eder,  Ronald Esser,  Roland Feifel,  Richard Heng,  Peter Hiestand,  Benedicte Jachez-Demange,  Pius Loetscher,  Helmut Sparrer,  Achim Schlapbach,  Rudolf Waelchli
Affiliations

Affiliation

  • 1 Novartis Institutes for BioMedical Research, Global Discovery Chemistry, Autoimmunity and Transplantation, CH-4002 Basel, Switzerland. Laszlo.revesz@novartis.com
PMID: 16198561 DOI: 10.1016/j.bmcl.2005.08.057
Abstract

Cinnamides as novel CCR1 Antagonist chemotypes are described with high affinity to human and rodent receptors. A1B1 and A4B7 showed oral activity in the mouse collagen induced arthritis.

Figures
Products
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z