1. Academic Validation
  2. Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri

Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri

  • Biol Pharm Bull. 2006 Jan;29(1):177-9. doi: 10.1248/bpb.29.177.
Toru Iizuka 1 Hiroyoshi Moriyama Masahiro Nagai
Affiliations

Affiliation

  • 1 Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan. iizuka@hoshi.ac.jp
Abstract

Methyl brevifolincarboxylate (1) isolated from the leaves of Phyllanthus niruri L. showed a vasorelaxant effect on rat aortic rings. Compound 1 exhibited slow relaxation activity against norepinephrine (NE)-induced contractions of rat aorta with or without endothelium. The compound did not affect contractions induced by a high concentration (60 mM) of K+, whereas it inhibited NE-induced vasocontraction in the presence of nicardipine. These results suggest that the inhibition of NE-induced vasocontraction by compound 1 is in part attributable to a decrease in [Ca2+]i through receptor-operated Ca2+ channels.

Figures
Products