2. Academic Validation
  3. Novel skeleton terpenes from Celastrus hypoleucus with anti-tumor activities

Novel skeleton terpenes from Celastrus hypoleucus with anti-tumor activities

  • Bioorg Med Chem Lett. 2006 Apr 15;16(8):2274-7. doi: 10.1016/j.bmcl.2006.01.021.
Kui-wu Wang 1,  Jian-shan Mao,  Yuan-po Tai,  Yuan-jiang Pan
Affiliations

Affiliation

  • 1 Department of Chemistry, Zhejiang University, Hangzhou 310027, PR China.
PMID: 16455245 DOI: 10.1016/j.bmcl.2006.01.021
Abstract

Celahypodiol 1, an unusual 17-membered carbon diterpenoid with a novel skeleton, and a new triterpenoid 12-oleanene-3beta,6alpha-diol 2, together with four known compounds furreginol 3, suigol 4, 20(30)-lupene-3beta, 29-diol 5, and 20(29)-lupene-1beta,3beta-diol 6, were isolated from the stalks of Celastrus hypoleucus (Oliv.) Warb. Their structures were established by means of spectroscopic analysis, including 2D NMR. The new compounds exhibited anti-tumor activities against a panel of human tumor cell lines.

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