2. Academic Validation
  3. New gemacranolides from Eupatorium hualienense

New gemacranolides from Eupatorium hualienense

  • Chem Biodivers. 2005 Feb;2(2):244-52. doi: 10.1002/cbdv.200590007.
Ya-Ching Shen 1,  Jiun-Yang Jang,  Ashraf Taha Khalil,  Lien Chai Chiang
Affiliations

Affiliation

  • 1 Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan 80424, Republic of China.
PMID: 17191977 DOI: 10.1002/cbdv.200590007
Abstract

Phytochemical investigation of Eupatorium hualienense (C. H. Ou, S. W. Chung, C. I. Peng) has resulted in the isolation of the new sesquiterpene lactones 1-5, named eupahualins A-E, along with the known heliangolide eupasimplicin B (6). The structures of the isolated compounds were established through detailed spectral analyses, especially by means of 2D-NMR techniques. Compounds 1-4 and 6 showed significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone Cancer (U2OS).

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