2. Academic Validation
  3. Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines

Novel 1,4-benzodiazepine derivatives with antiproliferative properties on tumor cell lines

  • Bioorg Med Chem Lett. 2007 May 1;17(9):2527-30. doi: 10.1016/j.bmcl.2007.02.016.
Jennifer Dourlat 1,  Wang-Qing Liu,  Nohad Gresh,  Christiane Garbay
Affiliations

Affiliation

  • 1 Université Paris Descartes, UFR Biomédicale, Laboratoire de Pharmacochimie Moléculaire et Cellulaire, Paris F-75006, France.
PMID: 17317183 DOI: 10.1016/j.bmcl.2007.02.016
Abstract

Novel 1,4-benzodiazepine compounds were synthesized and evaluated for their ability to inhibit the proliferation of tumor cells. Some compounds revealed activities in the micromolar range and were more efficient than reference compound Ro 5-4864. Preliminary SAR helped to identify critical motifs for antiproliferative activity and led to the discovery of a compound selective for a melanoma cell line, known for its resistance to chemotherapy.

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