2. Academic Validation
  3. A novel ansamycin, naphthomycin K from Streptomyces sp

A novel ansamycin, naphthomycin K from Streptomyces sp

  • J Antibiot (Tokyo). 2007 Oct;60(10):649-53. doi: 10.1038/ja.2007.84.
Chunhua Lu 1,  Yuemao Shen
Affiliations

Affiliation

  • 1 Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen Engineering Research Center of Marine Microbial Drug Discovery, School of Life Science, Xiamen University, Fujian, PR China.
PMID: 17965482 DOI: 10.1038/ja.2007.84
Abstract

One novel ansamycin, namely naphthomycin K, together with two known naphthomycins A and E, were isolated from the commensal strain Streptomyces sp. CS of the medicinal plant Maytenus hookeri. Their structures were elucidated by the analysis of NMR and MS data. Naphthomycin K showed evident cytotoxicity against P388 and A-549 cell lines, but no inhibitory activities against Staphylococcus aureus and Mycobacterium tuberculosis.

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