2. Academic Validation
  3. Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits

Antibacterial C-geranylflavonoids from Paulownia tomentosa Fruits

  • J Nat Prod. 2008 Apr;71(4):706-9. doi: 10.1021/np070446u.
Karel Smejkal 1,  Stanislav Chudík,  Pavel Kloucek,  Radek Marek,  Josef Cvacka,  Marie Urbanová,  Ondrej Julínek,  Ladislav Kokoska,  Tereza Slapetová,  Pavla Holubová,  Ales Zima,  Margita Dvorská
Affiliations

Affiliation

  • 1 Department of Natural Drugs, University of Veterinary and Pharmaceutical Sciences Brno, Palackého 1-3, CZ-612 42 Brno, Czech Republic. karel.mejkal@post.cz
PMID: 18293924 DOI: 10.1021/np070446u
Abstract

Eight C-6-geranylflavonoids ( 1- 8) were isolated from an ethanol extract of Paulownia tomentosa fruits. Tomentodiplacone ( 1), 3'- O-methyl-5'-hydroxydiplacone ( 2), 3'- O-methyl-5'- O-methyldiplacone ( 3), and tomentodiplacone B ( 4) were obtained as new compounds, and 3'- O-methyldiplacol ( 5) was isolated for the first time from a natural source. The structures of these new compounds were determined by using mass spectrometry (including HRMS) and 1D and 2D NMR spectroscopy, and the absolute configurations of the compounds were determined by circular dichroism. The Antibacterial activities of 1- 8 against seven bacteria and yeast were evaluated.

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