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  3. Total synthesis of pteridic acid A

Total synthesis of pteridic acid A

  • Org Lett. 2010 Jan 15;12(2):348-50. doi: 10.1021/ol9026842.
J S Yadav 1,  V Rajender,  Y Gangadhara Rao
Affiliations

Affiliation

  • 1 Organic Chemistry Division-1, Indian Institute of Chemical Technology, Hyderabad 500 007, India. yadaVpub@iict.res.in
PMID: 20020735 DOI: 10.1021/ol9026842
Abstract

A convergent approach to the total synthesis of pteridic acid A, having potent plant growth regulator activity, is described. Key steps include the desymmetrization of bicyclic olefin with Brown's chiral hydroboration, acid-mediated spiroketalization, and zirconium-catalyzed ethylmagnesation protocol to install the ethyl stereocenter at C14.

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