2. Academic Validation
  3. Acetamide derivatives with antioxidant activity and potential anti-inflammatory activity

Acetamide derivatives with antioxidant activity and potential anti-inflammatory activity

  • Molecules. 2010 Mar 23;15(3):2028-38. doi: 10.3390/molecules15032028.
Giuseppina Autore 1,  Anna Caruso,  Stefania Marzocco,  Barbara Nicolaus,  Chiara Palladino,  Aldo Pinto,  Ada Popolo,  Maria S Sinicropi,  Giuseppina Tommonaro,  Carmela Saturnino
Affiliations

Affiliation

  • 1 Department of Pharmaceutical Sciences, University of Salerno, Fisciano (SA), Italy. autore@unisa.it
PMID: 20336030 DOI: 10.3390/molecules15032028
Abstract

This study reports the synthesis and antioxidant activity of some new acetamide derivatives. The compounds' structures were elucidated by NMR analysis and their melting points were measured. The in vitro antioxidant activity of these compounds was tested by evaluating the amount of scavenged ABTS radical and estimating ROS and NO production in tBOH- or LPS-stimulated J774.A1 macrophages. All compounds were tested for their effect on cell viability by an MTT assay and by a Brine Shrimp Test.

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