1. Academic Validation
  2. Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia

Germacrane-type sesquiterpenoids from the roots of Valeriana officinalis var. latifolia

  • J Nat Prod. 2010 Sep 24;73(9):1563-7. doi: 10.1021/np100452a.
Peng-Cheng Wang 1 Xin-Hui Ran Rui Chen Huai-Rong Luo Yu-Qing Liu Jun Zhou You-Xing Zhao
Affiliations

Affiliation

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Abstract

Eight new germacrane-type sesquiterpenoids, volvalerenals A-E (2-6) and volvalerenic acids A-C (7-9), along with four known compounds, were isolated from a chloroform extract of the roots of Valeriana officinalis var. latifolia. The structures and relative configurations of 2-9 were elucidated on the basis of spectroscopic data interpretation. The effects of all compounds isolated on acetylcholinesterase were evaluated.

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