2. Academic Validation
  3. Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621

Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621

  • Arch Pharm Res. 2012 Mar;35(4):639-45. doi: 10.1007/s12272-012-0407-1.
Girish Chandra 1,  Varughese Alexander,  Hyuk Woo Lee,  Lak Shin Jeong
Affiliations

Affiliation

  • 1 Department of Bioinspired Science and Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.
PMID: 22553056 DOI: 10.1007/s12272-012-0407-1
Abstract

An improved synthesis of DNA-dependent protein kinase inhibitor, IC86621 is described. This developed method provides an easy access to this simple molecule by using amination, acetylation and Fries rearrangement reactions.

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