2. Academic Validation
  3. Reengineered epipodophyllotoxin

Reengineered epipodophyllotoxin

  • Chem Commun (Camb). 2012 Oct 28;48(84):10416-8. doi: 10.1039/c2cc35044k.
Igor V Magedov 1,  Nikolai M Evdokimov,  Menuka Karki,  Amanda S Peretti,  Dustin T Lima,  Liliya V Frolova,  Mary R Reisenauer,  Anntherese E Romero,  Paul Tongwa,  Alexandr Fonari,  Jeff Altig,  Snezna Rogelj,  Mikhail Yu Antipin,  Charles B Shuster,  Alexander Kornienko
Affiliations

Affiliation

  • 1 Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, New Mexico 87801, USA. imagedov@nmt.edu
PMID: 22986348 DOI: 10.1039/c2cc35044k
Abstract

A variant structural skeleton of epipodophyllotoxin was synthesized and found to rival the natural cyclolignan in antiproliferative and microtubule destabilizing properties. This discovery leads to a new structural class of tubulin targeting agents.

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